摘要
目的探讨维持性血液透析对慢性肾功能衰竭(CRF)患者C-反应蛋白、白介素-6和脂蛋白(a)的影响。方法以36例进行维持性血液透析的CRF患者为研究对象,36例健康体检者为对照组。分别测定试验初次、3个月后、6个月后、12个月后的每次血液透析前、后的CRP、IL-6和Lp(a)水平。结果 CRF患者血液透析前CRP、IL-6和Lp(a)均显著高于对照组,差异有统计学意义(P<0.05),而每次血液透析前后CRP、IL-6和Lp(a)比较,差异均无统计学意义(P>0.05),试验初次、3个月后、6个月后、12个月后的CRP、IL-6和Lp(a)比较,差异均有统计学意义(P<0.05)。结论 CRF患者普遍存在微炎症状态和高Lp(a)血症,血液透析并不能降低患者的CRP、IL-6和Lp(a)水平,对于维持性血液透析的CRF患者,有必要进行抗炎和降血脂治疗,防止心血管疾病的发生。
Objective To study the effects of maintained hemodialysis on C -reactive protein（CRP）, interleukin- 6（ IL- 6） and lipoprotein（a） [ Lp（a） ] in patients with chronic renal failure. Methods 36 cases of CRF patients with maintenance hemodialysis were studied, and 30 healthy persons were served as control group. The levels of CRP, IL - 6 and Lp（a） were measured before and after hemodialysis the first, 3 months, 6 month% 12 months, respectively. Results Before hemodialysis, the level of the serum CRP, IL - 6 and Lp （a） of the patients with chronic renal failure were significantly higher than the control group, and the difference was statistically significant（P 〈 0. 05）. Every time the difference of CRP, IL -6 and Lp （a） before and after hemodialysis was not statistically significant （ P 〉 0. 05 ）. After the first, 3 months, 6 months, 12 months hemodialysis, the level of the serum CRP, IL - 6 and Lp （a） were statistically significant （P 〈 0.05）. Conclusion The patients with chronic renal failure were inflammatory state and high lipoprotein hematic disease. Maintained hemodialysis can not reduce the level of CRP, IL, 6 and Lp（a）. Anti - inflammatory and reducing lipoprotein（a） were necessary to prevent cardiovascular dis-
出处
《中国卫生检验杂志》
CAS
2016年第1期57-58,61,共3页
Chinese Journal of Health Laboratory Technology
基金
国家863计划子课题(2011AA02A111)
