老年梅毒感染患者血清抗核抗体检测的临床意义

Detection of serum antinuclear antibody of the elder patients with syphilis and its clinical significance

目的探讨检测老年梅毒感染患者血清抗核抗体(ANA)的临床意义。方法选择2013年1月-2014年12月在本院就诊或住院的264例老年梅毒感染患者为研究对象,200例血清梅毒抗体检测结果为阴性的老年健康体检者为对照组,用间接免疫荧光法(IFA)对2组老年人血清中的ANA进行检测,统计分析2组老年人ANA阳性率和核型分布。结果老年梅毒感染患者中125例ANA阳性,阳性率为47.3%,而健康对照组老年人中33例ANA阳性,阳性率为16.5%;梅毒抗体阳性组老年人ANA阳性率明显高于健康对照组,差异有统计学意义(P<0.05)。梅毒抗体阳性合并ANA阳性老年患者中,ANA核型以染色体型和胞浆颗粒型为主。结论老年梅毒感染患者往往合并自身免疫反应,检测ANA有利于评估和防治老年梅毒感染患者自身免疫性疾病的发生。

Objective To explore the clinical significance of antinuclear antibody （ANA） detection of the elder patients with syphilis infection. Methods 264 elder patients with syphilis infection diagnosed in our hospital from January 2013 to December 2014 were selected as study objects; 200 healthy elder persons whose detection results of antibody to treponema pallidum were negative were chosen as control group. ANA in the serum of the two elder groups were detected by indirect immunofluoreseence （IFA）. The positive rates of two groups and the nuclear distribution were statistically analyzed. Results There were 125 positive cases among the elder patients with syphilis infection with the positive rate of 47.3 % , whereas 33 positive cases were among healthy elder controls with the positive rate of 16.5%. The positive rates of ANA in the syphilis antibody positive group was significantly higher than that in the healthy control group, and the difference was statistically significant （P 〈 0.05 ）. The main positive types of ANA in experimental group were chromosome and cytoplasmic granules among the elder patients with positive syphilis antibody combined with ANA positive. Conclusion There is often autoimmune in the elder patients with syphilis infection, and the detection of ANA is helpful for the evaluation, prevention and treatment of autoimmune disease for them.