血清降钙素原、C-反应蛋白和白细胞介素-6在不同年龄细菌性肺炎患者中的研究

Study of serum procalcitonin,C-reactive protein and interleukin-6 in patients with bacterial pneumonia at different ages

目的对不同年龄细菌性肺炎(BP)患者进行血清降钙素原(PCT)、C-反应蛋白(CPR)和白细胞介素-6(IL-6)水平相关性分析,并探讨其临床意义。方法收集326例细菌性肺炎患者,其中18岁~35岁患者112例,为青年组;36岁~60岁患者106例,为中年组;>60岁患者108例,为老年组。分别对患者住院24 h内、治疗3 d^5 d后、出院前1 d采集静脉血8.0 ml,检测血清PCT、CPR、IL-6水平,并对其进行对比分析及Pearson线性相关分析。应用ROC曲线评价PCT、CRP和IL-6在不同年龄的BP患者中的诊断价值。结果与对照组比较,青年组、中年组及老年组PCT、CRP和IL-6水平明显升高,差异具有统计学意义(P<0.01);青年组PCT和CRP水平明显高于老年组,差异具有统计学意义(P<0.01),老年组和青年组IL-6水平明显高于中年组,差异具有统计学意义(P<0.05)。老年组治疗前、治疗中、治疗后PCT与CRP呈明显正相关(P<0.01)。中年组和老年组治疗后PCT与IL-6呈明显正相关(P<0.05)。结论 PCT、CRP和IL-6水平与各组BP患者具有一定的相关性,对细菌性肺炎的诊断及疗效具有一定的临床意义,且PCT优于CRP和IL-6。

Objective To analyze the correlation of serum procalcitonin, C - reactive protein and interleukin - 6 levels in patients with bacterial pneumonia（BP） at different ages, and to explore its clinical significance. Methods 326 cases of bacterial pneumonia patients were collected, among which 112 cases were 18 -35 years old, as the youth group, 106 cases were 36 -60 years old, as the middle age group, and 108 cases were above 60 years old, as the elderly group. 8.0 ml venous blood was collected from hospital patients respectively within 24 h, at 3 d - 5 d, and 1 d before discharge, and the levels of serum PCT, CRP and IL -6 were detected, and the correlation analysis and Pearson linearity analysis were analyzed. Using ROC curve to evaluate the diagnostic value of PCT, CRP and IL - 6 in patients with bacterial pneumonia at different age stages. Results Com- pared with the control group, the PCT, CRP and IL - 6 levels of young group, middle age group and elderly group significantly increased, and the differences were statistically significant（ P 〈 0.01 ）. PCT and CRP levels of young group were significantly higher than the elderly group, and the differences were statistically significant（ P 〈 0.01 ）, the IL -6 levels of elderly group and youth group were significantly higher than the middle age group, and the differences were statistically significant （ P 〈 0.05 ）. And PCT were positively correlated with CRP before, during and after treatment in the elderly group （P 〈 0.01 ）. After treatment, and PCT were positively correlated with IL - 6 （P 〈 0.05）. Conclusion PCT, CRP and IL - 6 levels have certain relevance with bacterial pneumonia patients of groups, which has a certain clinical significance with the diagnosis and curative effect of bacterial pneumonia, with PCT superior to CRP and IL- 6.