妊娠期妇女不同孕期白细胞及血小板生理变化分析

Analysis of the physiological changes of leukocyte and platelet among pregnant women in different gestations

目的研究妊娠期妇女不同孕期外周血中白细胞(WBC)、中性粒细胞百分比(NEUT)及血小板(PLT)生理变化。方法收集2014年8月-2015年4月在北京世纪坛医院产前检查的健康孕妇63例,进行回顾性研究。结果孕中期WBC水平最高,与其他2组比较,差异有统计学意义(P<0.05)。孕中期、孕晚期NEUT水平较孕早期明显升高,差异有统计学意义(P<0.05)。PLT水平随孕周的增加呈降低趋势,差异有统计学意义(P<0.05)。孕晚期与临产期相比WBC、NEUT水平明显增高,差异有统计学意义(P<0.05);PLT水平差异无统计学意义(P>0.05)。结论与正常人相比,妇女妊娠期血常规相关参数均发生了很大的改变,正常参考范围不适用于妊娠期相关疾病的诊疗。

Objective The physiological changes of leukocyte（ WBC）,neutrophil percentage（ NEUT） and platelet（ PLT） were analyzed in pregnant women with different gestations. Methods 63 cases of healthy pregnant women were collected from the Beijing Shijitan Hospital during August,2014- April,2015 for retrospective study. Results The WBC level in the second gestation was the highest,and the differences with the other two groups were statistically significant（ P 〈0. 05）. The NEUT levels in the mid gestation and the late gestation rose higher than that in the early gestation,and the differences were statistically significant（ P 〈0. 05）. The count of PLT reduced gradually along the whole gestations,and the differences were statistically significant（ P 〈0. 05）. The WBC and NEUT levels on parturient period were significance higher than the pre- parturient period,and the differences were statistically significant（ P 〈0. 05）. While the differences on PLT had no statistical significance（ P 〉0. 05）. Conclusion There were physiological changes on the counts of WBC,NEUT,and PLT during the whole gestations,therefore,the normal range of whole blood rountine test is not suitable for the diagnosis and treatment of pregnancy related diseases.