糖皮质激素治疗难治性支原体肺炎

Efficacy of glucocorticoid therapy on refractory mycoplasma pneumonia

目的：探讨糖皮质激素治疗难治性支原体肺炎的临床效果。方法选取2014年4月至2014年12月在灵丘县人民医院接受治疗的48例难治性支原体肺炎患者，将其按照年龄、病情等随机分为对照组和试验组，每组24例。对照组采用大环内酯类抗生素序贯治疗方式，试验组在对照组基础上加用甲强龙、强的松药物治疗方式，比较两组患者的治疗效果。结果对照组治疗有效率为41.67％，试验组为87.50％，两组比较差异有统计学意义（ P＜0.05）；试验组C-反应蛋白、血沉、外周血中性粒细胞等明显优于对照组，两组比较差异有统计学意义（ P＜0.05）。两组患者均未发生不良反应。结论糖皮质激素应用于难治性支原体肺炎疾病的临床治疗中可以有效提高其治疗有效率，改善其临床症状，值得临床推广应用。

Objective To investigate the clinical effect of glucocorticoid treatment on refractory mycoplasma pneumonia .Methods From April 2014 to December 2014, fourty eight patients with refractory mycoplasma pneumonia in our hospital were randomly divided into control group and test group with 24 patients in each group .The patients in the control group were treated with macrolide antibiotics sequential treatment , and the patients in the test group were given methylprednisolone , prednisone drug treatment in addition , the treatment effects of the two groups were compared .Results The effective rate in the control group was 41.67%, that in the test group was 87.50%, there was significant difference between the two groups（P〈0.05）;C-reactive protein, erythrocyte sedimentation rate, peripheral neutrophils was significantly better in the test group than those in the control group , there were significant differences between the two groups （ P〈0.05） .There were no adverse reactions in the two groups .Conclusions Corticosteroids can effectively improve the treatment effect on refractory mycoplasma pneumo-nia, improve the clinical symptoms, so is worthy of clinical application.