美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的临床疗效比较

Comparison of treatment effect evaluation of mesalazine and sulfasalazine to treat ulcerative colitis

目的：比较美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的临床效果。方法选取济源市人民医院消化内科2013年4月至2014年4月收治的100例溃疡性结肠炎患者，随机分为美沙拉嗪组（ A组）与柳氮磺吡啶组（ B组），每组50例，比较两组的治疗效果。结果 A组和B组临床总有效率分别为96％和80％，差异有统计学意义（ P＜0.05）。 A组头痛1例，腹泻1例，不良反应率为4％；B组腹痛2例，白细胞减少2例，恶心2例，头痛3例，不良反应率为18％，两组比较差异有统计学意义（ P＜0.05）。不良反应均经对症处理后好转。结论溃疡性结肠炎患者采用美沙拉嗪治疗具有较高的有效性和安全性，可显著改善预后，特别是对磺胺类抗生素无法耐受的患者，采用美沙拉嗪可取得较好的疗效，对提高患者生存质量、保障身心健康有非常重要的作用。

Objective To investigate clinical effect of using mesalazine and sulfasalazine on ulcerative colitis . Methods One hundred cases of ulcerative colitis who were admitted at Digestive System Department in our hospital from April 2013 to April 2014 were selected.They were randomly divided into group A and group B equally and received Mesalazine treatment and Sulfasalazine treatment seperately , then effects were contrasted .Results Total clinical effective rate of ulcerative colitis patients of group A was 96%, and that of group B was 80%, the difference was significant （ P〈0.05）.In group A, 1 case had headache, 1 case had diarrhea, the adverse reaction rate was 4%.In group B, 2 cases had abdominal pain , 2 cases had leukopenia , 2 cases had nausea symptom , 3 cases had headache and the adverse reaction rate was 18%.The adverse reactions had significant difference （P〈0.05）.Adverse reactions were all improved after symptomatic treatment.Conclusions Using mesalazine on ulcerative colitis patients has higher validity and security , it can contribute to ideal improvement of prognosis .Especially for patients who can ’ t tolerate sulfa antimicrobial drugs , the use of mesalamine can achieve effective results and plays an important role in safeguarding patients ’ quality of life and improving their physical and mental health .