左氧氟沙星联合替硝唑与常规疗法治疗急性盆腔炎的疗效及安全性比较

Comparison of Efficacy and Safety of Levofloxacin Combined With Tinidazole and Conventional therapy in Treatment of Acute Pelvic Inflammation

目的比较左氧氟沙星联合替硝唑与常规疗法治疗急性盆腔炎的疗效及安全性。方法选择2012年12月至2014年11月期间收治的急性盆腔炎患者90例,按随机数字表法分为观察组和对照组,每组各45例。对照组患者给予常规疗法治疗,观察组患者给予左氧氟沙星联合替硝唑治疗。对治疗后2组患者的临床症状消失时间、C反应蛋白(CRP)水平、盆腔包块大小及不良反应发生率进行比较。结果治疗后观察组患者的临床症状消失时间明显短于对照组,差异有统计学意义(P<0.05)。治疗后观察组患者的CRP水平明显低于治疗前和对照组,差异有统计学意义(P<0.05)。治疗后观察组患者的盆腔包块明显小于治疗前和对照组,差异有统计学意义(P<0.05)。观察组患者治疗后恶心呕吐、头晕头痛及其他不良反应的发生率明显低于对照组,差异有统计学意义(P<0.05)。结论对急性盆腔炎患者进行左氧氟沙星联合替硝唑治疗,可明显减轻临床症状和盆腔包块,降低CRP水平和不良反应发生率。

Objective To compare the efficacy and safety of levofloxacin combined with tinidazole and conventional therapy in the treatment of acute pelvic inflammation.Methods Totally90 patients with acute pelvic inflammation who were treated between December 2012 and November 2014 were randomly assigned to receive either conventional therapy（control group,n=45）or combined levofloxacin and tinidazole treatment（observation group,n=45）.The time to clinical symptom disappearance,level of C-reactive protein（CRP）,size of pelvic mass,and incidence of adverse reactions were compared between the two groups.Results In observation group,the level of CRP and size of pelvic mass significantly reduced after treatment（P〈0.05）.Compared with control group,the time to clinical symptom disappearance,level of CRP,size of pelvic mass,and incidence of nausea,vomiting,dizziness,headache and other adverse reactions significantly decreased in observation group after treatment（P〈0.05）.Conclusion The combined treatment with levofloxacin and tinidazole can alleviate clinical symptoms and reduce level of CRP,size of pelvic mass and incidence of adverse reactions in patients with acute pelvic inflammation.