抗炎镇痛液皮损区皮内注射联合加巴喷丁口服与直线偏振光照射治疗带状疱疹后神经痛的疗效

Effect of intradermal anti-inflammatory analgesic solution combined with oral gabapentin and linear polarized light irradiation on the painful area in the treatment of postherpetic neuralgia

目的 探讨复方倍他米松、腺苷钴胺与利多卡因复合液皮损区皮内注射联合口服加巴喷丁与疼痛区直线偏振光照射治疗带状疱疹后神经痛（PHN）的疗效.方法 带状疱疹后神经痛患者130例,随机分为注射组（n=66）和阻滞组（n=64）,注射组给予患者皮损区皮内注射抗炎镇痛液;阻滞组行疼痛区支配神经椎旁神经阻滞.两组患者同时行偏振光照射与加巴喷丁胶囊口服治疗.观察两组患者在治疗前及治疗后24 h、2周、1个月时视觉模拟评分（VAS）和睡眠质量,并评估疗效.结果 治疗后24 h,两组VAS及睡眠质量差异无统计学意义（P＞0.05）,治疗2周及1个月后皮丘注射组VAS值（2.00±1.02）、睡眠时间（8.00±1.38） h/d明显优于神经阻滞组（P＜0.05）,治疗1个月后VAS评分下降率皮内注射组为98.5％,而神经阻滞组为86.1％,数据显示皮内注射组疗效明显优于神经阻滞组.结论 皮损区皮内注射抗炎镇痛液联合口服加巴喷丁与疼痛区直线偏振光照射治疗带状疱疹后神经痛是一种有效的治疗方法.

Objective To study the efficacy of intradermal injection with anti-inflammatory analgesic solution combined with oral gabapentin and linear polarized light irradiation on the painful area in the treatment of postherpetic neuralgia （PHN）.Methods One hundred and thirty patients with postherpetic neuralgia （PHN） were randomly divided into injection group （n=66） and block group （n=64）.All patients received oral gabapentin and linear polarized light irradiation on the painful area.Patients in injection group received intradermal anti-inflammatory analgesic solution, and in block group received paravertebral nerve block distributed to the pain zone.The visual analogue scale （VAS） and sleep quality of all patients were recorded before and at 24 hours, 2 weeks and 1 month after treatment respectively, and the effect was evaluated.Results There were no significant difference between the two groups in the VAS and sleep quality （P〉 0.05） at 24 hours after treatment.But the VAS and sleep quality were significantly better in injection group than those in block group （P 〈0.05） at 2 weeks and 1 month after treatment.Conclusion Intradermal injection with anti-inflammatory analgesic solution combined with oral gabapentin and linear polarized light irradiation on the painful area is an effective method to treat postherpetic neuralgia.