直接重编程用于心脏再生治疗的研究进展

The Research Progress of Direct Reprogramming for Cardiac Regeneration

心脏再生治疗有望改变现有的心血管病治疗局面,直接重编程领域的研究为实现这一目标提供了新的有力工具。直接重编程是近年来广泛应用于细胞修复及器官移植研究的一项技术,可绕过诱导多功能干细胞中间阶段,直接将一种终末分化细胞转化为其他种类的终末分化细胞。总结了直接重编程用于心脏再生治疗的研究进展,探讨直接重编程技术尚存的问题和障碍,并展望其未来在再生医学领域的应用。

Cardiac regeneration is expected to change the existing treatment situation of cardiovascular disease. Research in the field of direct reprogramming provides a new powerful tool to achieve this goal. Direct reprogramming is widely used for studies on cell repair and organ transplantation recent years, which can by pass the middle stage of induced pluripotent stem cells, change one terminallydifferentiated cell type directly into another. The developments of direct reprogramming in the heart repair were summarized, the controversies and obstacles that challenge the field were pointed out, and the applications of this technology in the field of cardiovascular regenerative medicine in the future were explored.