结直肠癌去整合素-金属蛋白酶-9表达与预后的关系

Relationship between expression of a disintegrin and metalloproteinase-9 and prognosis in colorectal cancer

目的探讨结直肠癌去整合素-金属蛋白酶-9(ADAM-9)表达与临床病理因素、预后的关系。方法应用免疫组化检测不同临床分期结直肠癌(72例)ADAM-9表达,术后随访分析与结直肠癌患者预后的相关性。结果在结直肠正常组织ADAM-9表达阴性,癌组织中高表达,其阳性率为(69.4%,50/72)明显高于正常组织(P<0.05);ADAM-9表达与结直肠癌患者性别、年龄、肿瘤大小、组织学类型无差异,但与肿瘤侵犯深度、淋巴结转移,TNM分期相关(P<0.05);Kaplan-Meier生存分析显示,ADAM-9表达阳性结肠腺癌患者术后生存期明显低于阴性表达者(P<0.05)。结论 ADAM-9表达与肿瘤TNM分期、浸润深度、淋巴结转移呈正相关,与术后复发时间呈负相关,提示ADAM-9可作为预测结肠癌生存期的指标,用于术后复发风险的评估。

Objective To investigate the correlation of expression of a disintegrin and metalloproteinase-9 （ADAM- 9） with clinicopathological factors and prognosis in colorectal cancer. Methods The expression of ADAM-9 in 72 cases of colorectal cancer of different clinical stages was detected by immunohistochemistry, and its correlation with prognosis was analyzed. Results ADAM-9 was overexpresssed in cancer tissues（69.4%, 50/72） and negatively expressed in normal tissues, with significant differences（P〈0.05）. The expression of ADAM-9 in colorectal cancer was associated with TNM stage, depth of invasion and lymph node metastasis （P〈0.05）, but was not related to gender, age, tumor size and histological type.Kaplan-Meier survival analysis revealed that the survival time of patients with positive expression of ADAM-9 was significantly lower than that of patients with negative expression （P〈0.05）. Conclusions The expression of ADAM-9 in colorectal cancer is positively related to TNM stage, depth of invasion and lymph node metastasis, and is negatively related to the time of recurrence. ADAM- 9 may be a prognostic indicator of survival of colorectal cancer, and can be used in evaluation of recurrence after operation.