不同模式经直肠超声前列腺穿刺活检对前列腺癌Gleason评分影响的研究

The effect of different modes of the prostate biopsy on the Gleason score of prostate cancer

目的：探讨不同模式经直肠超声前列腺穿刺活检对前列腺癌（prostate cancer, PCA）Gleason评分的影响。方法对95例已确诊的PCA进行回顾性研究，不同模式的经直肠前列腺穿刺活检共4组，即系统穿刺活检组（SB组）28例，仅行对比增强靶向活检组（CEUS组）15例，仅行弹性成像靶向活检组（UE组）28例，CEUS联合UE靶向活检组（CUES＋UE组）24例。将得到的Gleason评分进行组间比较。结果 SB组与CEUS组之间、CEUS组与UE组间、CEUS＋UE组两两之间的差异均无统计学意义（P＞0.05），而UE组、CUES＋UE组与SB组的Gleason评分的差异均有统计学意义（P＜0.05）。结论与经直肠超声引导下前列腺系统活检相比，经直肠超声弹性成像技术、经直肠对比增强超声联合超声弹性成像技术引导的前列腺靶向活检有助于得到较高的前列腺组织Gleason评分。

Objective To investigate the effect of different patterns of the prostate biopsy on Gleason score of prostate cancer （PCA）.Methods A total of 95 patients with different biopsy patterns were randomly divided into 4 groups including sysmetic biopsy group（SB, 28 cases）, contrast enhanced ultrasound group （CEUS, 15 cases）, ultrasonic elastography group （UE, 28 cases）, the group of CEUS combined with UE （CUES＋UE, 24 cases）. The Gleason scores were comparatively analyzed between groups.Results There was no significant difference in Gleason score between SB group and CEUS group, as well as CEUS group, UE group and CEUS＋UE group （P〉0.05）, whereas there were significant differences（P〈0.05） between SB group and UE group, CUES＋UE group respectively.Conclusion CEUS combined with UE and UE targeted biopsy was superior to SB in obtaining higher Gleason score.