新型口服抗凝药活性监测方法的研究进展

A Review of Monitoring Methods of Non-vitamin K Antagonist Oral Anticoagulants

新型口服抗凝药的用药安全性监测方法可分为实验室检测和床边检测。对于实验室检测,相关的研究及指南已寻找到监测新型口服抗凝药的相对敏感指标,但各监测指标还没有公认的安全范围来评估该类药物与出血风险的关系;且各相对敏感指标是否为最佳监测指标,仍需进一步研究。涉及到床边检测的研究较少,目前有部分研究显示,床边检测方法用于监测新型口服抗凝药是可行的,但需要更多更系统的研究来验证。笔者从实验室检测和床边检测两方面,综述了新型口服抗凝药监测方法的最新研究进展,为临床安全用药提供参考。

Both laboratory monitoring and point-of-care testing （POCT）are the major two methods for monitoring of non-vitamin K antagonist oral anticoagulants. The safety interval of laboratory testing has not been estalished for surveillance and management of bleeding risk associated with NOACs, even though some sensitive measurements of the effects of these novel drugs have already been identified. Only a few studies investigated the effects of POCT, but most of them have positive results, Both laboratory monitoring and POCT are necessary to be evaluated in large clinical studies in patients receiving treatment with non-vitamin K antagonistoral anticoagulants. This paper reviews the latest research on monitoring non-vitamin K antagonist oral anticoagulants （NOACs）.