N,N-二甲基丙烯酰胺与丙烯酸的共聚物水凝胶对氯霉素的负载与缓释性能

The Load and Sustained Release Performance of Chloramphenicol in the Poly( DMAM-co-AA ) Hydrogels

目的 研究N,N-二甲基丙烯酰胺（DMAM）与丙烯酸（AA）的共聚物[Poly（DMAM-co-AA）]水凝胶对氯霉素的负载能力和缓释动力学。方法 将制得的干凝胶浸泡在氯霉素溶液中至充分溶胀饱和,测定凝胶对氯霉素的负载量;将负载氯霉素的干凝胶放入不同的溶液中不停搅拌,测定凝胶对氯霉素的释放速率。结果 发现随两种反应单体配比增大和氯霉素溶液浓度的增加,产物的氯霉素负载能力增大;该水凝胶对氯霉素的释放速率随温度升高而增大,在中性介质中释放速率较慢,在酸性和碱性介质中的释放速率均较快。结论 合成的水凝胶对氯霉素的负载能力随氯霉素溶液浓度的增大而增大,对负载氯霉素的释放可在8～12 h内完成,氯霉素的累计释放率可达到90%左右。

OBJECTIVE To study the load capacity and slow releasing kinetics of chloramphenicol in poly （DMAM-co-AA） hydrogel based on N,N-dimethyl acrylamide （DMAM） and acrylic acid（AA）. METHODS The dry hydrogel was soaked in chloramphenicol solution, fully saturated and swelled. The load capacity of chloramphenicol in the swelled hydrogel was investigated. The dry gel loaded chloramphenicol was put into the different solution and constantly stirred. At the same time, the release rate of chloramphenicol was studied. RESULTS When themole ratio of reaction monomers （DMAM/AA） and concentration of chloramphenicol solution were increased, the load capacityof chloramphenicol was increased. The release rate of chloramphenicol was increased with temperature rising. The release rate of chloramphenicolin acidic or alkaline medimn was larger than that in neutral medium. CONCLUSION The load capacity of chloramphenicol in poly（DMAM-co-AA） hydrogel is increased with the solution concentration of chloramphenicol increasing. The release of chloramphenicolin various hydrogels is completed in the range of 8 to 12 h, and the total release rate of chloramphenicol could reach about 90%.