肿瘤体积和放疗剂量对局部晚期非小细胞肺癌预后的影响分析

Effect of Tumor Volume and Radiotherapy Dose on the Prognosis of Patients With Locally Advanced Non Small Cell Lung Cancer

目的探讨肿瘤体积和放疗剂量对局部晚期非小细胞肺癌预后的影响。方法选取我院2011年2月~2012年2月收治的90例局部晚期非小细胞肺癌患者,所有患者均采用三维适形治疗,根据治疗结果分析肿瘤体积和放疗剂量对局部晚期非小细胞肺癌预后的影响。结果肿瘤最大直径〈5.00 cm、GTV-P〈90.00 cm^3、GTV-T〈100 cm^3以及放疗剂量为〈60 Gy和〉70 Gy的患者生存率更高,明显高于肿瘤直径〉5.00 cm、GTV-P〉90.00 cm^3、GTV-T〉100.00 cm^3以及放疗剂量在60~70 Gy的患者,差异有统计学意义（P〈0.05）,GTV-N〈15.0 cm^3和GTV-N〉15.00 cm^3的患者生存率无显著差异（P〉0.05）。结论局部晚期非小细胞肺癌患者的肿瘤体积和放疗剂量对患者的生存率有直接影响,在对患者的治疗中根据肿瘤体积控制放疗剂量能够有效改善患者预后效果。

Objective To investigate the effect of tumor volume and radiotherapy dose on the prognosis of patients with locally advanced non-small cell lung cancer. Methods From February 2011 ~ February 2012,90 cases of locally advanced non small cell lung cancer were treated with 3D conformal therapy. According to the results of treatment of tumor volume and dose of radiotherapy for locally advanced non small cell lung cancer prognosis. Results Maximum tumor diameter 〈5.00 cm, gtv-P 〈90.00 cm^3, gtv-t 100 cm^3 and radiotherapy dose for 〈60 Gy and〉 70 Gy in patients who survive rate higher, significantly higher than the tumor diameter 〉5.00 cm, gtv-P 〉90.00 cm^3, gtv-t〉 100.00 cm^3 and radiation dose in patients with 60~70 Gy. Significant difference（P〈0.05）, And 〈15.0 cm^3 〉15.00 cm^3 patient survival rate had no significant difference（P〈0.05）. Conclusion Locally advanced non survival of patients with small cell lung cancer tumor volume and radiation dose to the patient＇s rate has a direct impact on treatment of patients according to tumor volume control dose radiotherapy can effectively improve the prognosis of patients with effect.