盐酸多奈哌齐治疗老年痴呆的临床分析

Clinical Analysis on Donepezil Hydrochloride in Treatment of Senile Dementia

目的分析盐酸多奈哌齐治疗老年痴呆的效果。方法研究2015年1月~2015年11月,纳入老年痴呆共48例,随机分组。常规治疗者有23例,为对照组;盐酸多奈哌齐治疗者有25例,为研究组。对比效果。结果两组中研究组的治疗有效率更高,MMSE和ADL评分改善更明显,不良反应率更低,有显著差异（P〈0.05）,且具统计学意义。结论盐酸多奈哌齐对老年痴呆治疗效果佳。

Objective Clinical effect of Donepezil Hydrochloride in treatment of senile dementia was to be studied. Methods Choose 48 elderly patients of senile dementia who are treated in hospital from January 2015 to November 2015 and separated 23 patients into control group that were given conventional treatment, while another 25 patients are taken into study group were given Donepezil Hydrochloride treatment and then observed and compared treatment effects between two groups. Results Patients＇ treatment efficacy was much higher and their MMSE and ADL assessment scores were improved much more favorable in study group and patients＇ side-effect incidence was much lower compared to that in control group; there was a differential between two groups and such a differential has statistic value（P〈0.05）. Conclusion Donepezil Hydrochloride was effective in treatment of senile dementia.