亚急性坏死性脊髓病的研究进展

Research progress of subacute necrotizing myelopathy

亚急性坏死性脊髓病(SNM)是一种罕见的神经系统副肿瘤综合征(PNS),是原发肿瘤引起的免疫反应导致的脊髓非炎症性坏死,临床多表现为横贯性的脊髓损害症状,早期诊断较为困难,目前尚缺乏公认有效的治疗方法,致残致死率高,预后不良。文章通过结合国内外相关文献,对SNM的研究背景、发病机制、临床及影像学特点、诊断治疗及预后等进行阐述和回顾性分析,从而增强对SNM的了解,提高临床上对SNM的重视,进而为其早期诊断、干预提供指导。

Subacute necrotizing myelopathy （SNM）is a very rare paraneoplastic neurological syndromes of various malignancies. It＇s believed to be a kind of non-inflammatory necrosis in spinal which is caused by immune response. The manifestations of SNM were too complicated to be misdiagnostics easily in our clinical work. Besides, the lack of recognized effective treatment makes patients＇ prognosis poorly. Therefore, the early diagnosis is useful to treatment of the underling tumor. In order to enhance the understanding of SNM in clinical work, we retrospectively analyzed the background, pathogenesis, clinical and imaging features, diagnosis, treatment and prognosis of SNM through learning the domestic and foreign literature.