原发性高血压形成相关基础实验研究进展

Progress in basic experimental research related to the formation of primary hypertension

高血压是一种以动脉血压持续升高为特征的进行性"心血管综合征",是冠心病和脑卒中等心脑血管疾病的主要危险因素^([1])。研究并了解高血压的病因是对高血压认识和治疗的基础,不同的病因决定着不同的治疗方式和预防措施。目前对高血压的研究,不论是对高血压的病因研究,还是治疗药物研究,动物实验都有着举足轻重的作用。通过动物实验,对高血压的病因及发病机制的认识不断增多,发现高血压涉及的病因范围广,发病机制错综复杂,从而针对不同病因及发病机制研制了更多直接作用于病变部位及系统的药物,使治疗效果不断提高,同时尽可能减少药物对靶器官的损害。就高血压病因研究的重要性,按时间顺序将与原发性高血压形成有关的基础实验进行综述。

Hypertension is a kind of progressive cardiovascular syndrome that is characterized by continuously rising of arterial blood pressure, which is the main risk factor of cardiovascular and cerebrovascular diseases, such as coronary heart disease, stroke etc. The etiology of hypertension is the basis of cognition and therapy of it. The therapy and prevention of hypertension are determined by the causes of hypertension. Recently, there are many researches on hypertension, such as hypertension etiology research, antihypertensive drug research. Animal experiments play a great role in these researches. Through these animal experiments people have known more about the etiology and pathogenesis of hypertension. The causes of hypertension are involved in a wide range, and the pathogenesis is complicated. Therefore, according to different etiology and pathogenesis, people have developed more effective drugs acting directly on the lesion site and the system to enhance the treatment effects. At the same time, it is trying to reduce the drug damaging the target organ as much as possible. In this paper, in the light of the importance of the etiological research of hypertension, the progress of basic experimental research related to the formation of primary hypertension has been summarized by chronological order.