广东紫珠乙酸乙酯部位化学成分研究(Ⅱ)

Ethyl Acetate-Soluble Chemical Constituents from Callicarpa kwangtungensis( Ⅱ)

目的：研究广东紫珠乙酸乙酯部位的化学成分。方法：利用硅胶、Sephadex LH-20、MPLC等色谱方法进行分离纯化,根据化合物的理化性质、波谱分析方法进行结构鉴定。结果：从广东紫珠乙酸乙酯部位分离得到11个化合物,分别鉴定为：对甲氧基苯甲酸（1）、3,4-二羟基苯甲酸（2）、对羟基桂皮酸（3）、苯基-β-D-吡喃葡萄糖苷（4）、3,4,5-三甲氧基苯基-β-D-吡喃葡萄糖苷（5）、2α,3β,22β,23-四羟基-12-烯-28-乌苏酸（6）、2α,3β,6β,19α-四羟基乌苏烷-12-烯-28-O-β-D-吡喃葡萄糖苷（7）、2β,3β,6β,16α-四羟基齐墩果烷-12-烯-28-O-β-D-吡喃葡萄糖苷（8）、（3S,6E,10R）-10-β-D-吡喃葡萄糖-3,11-二羟基-3,7,11-三甲基-1,6-二烯（9）、icariside C5（10）、（2E,6E）-10-β-D-吡喃葡萄糖-1,11-二羟基-3,7,11-三甲基-2,6-二烯（11）。结论：其中,化合物4~11为首次从紫珠属植物分离得到,化合物1~3为首次从该植物中分离得到。

Objective： To study the ethyl acetate-soluble chemical constituents of Callicarpa kwangtungensis. Methods： The chemical constituents were isolated by column chromatography on silica gel,Sephadex LH-20 and MPLC. Their chemical structures were elucidated on the basis of special analysis. Results： Eleven compounds were isolated from the ethyl acetate-soluble part of Callicarpa kwangtungensis,whose structures were elucidated as 4-methoxybenzoic acid（ 1）,3,4-dihydroxybenzoic acid（ 2）,4-hydroxy cinnamic aicd（ 3）,phenyl-β-D-glucopyranoside（ 4）,3,4,5-trimethoxyphenyl-β-D-glucopyranoside（ 5）,2α,3β,22β,23-tetrahydroxyursolic-12-en-28-oic acid（ 6）,2α,3β,6β,19α-tetrahydroxy-urs-12-en-28-O-β-D-glucopyranoside（ 7）,2β,3β,6β,16α-tetrahydroxy-olean-12-en-28-O-β-D-glucopyranoside（ 8）,（ 3S,6E,10R）-10-β-D-glucopyranosyloxy-3,11-dihydroxy-3,7,11-trimethyldodeca-1,6-diene（ 9）,icariside C5（ 10）,and（ 2E,6E）-10-β-D-glucopyranosyl-1,11-dihydroxy-3,7,11-trimethyldodeca-2,6-diene（ 11）. Conclusion： Compounds 4 ~ 11 are isolated from Callicarpa genus for the first time,compounds 1 ~ 3 are isolated from this plant for the first time.