两面针根、茎抗击打损伤和镇痛抗炎作用比较研究

Comparative Study on Effects of Anti-contusion Injury,Analgesia and Anti-inflammation of Root and Stem of Zanthoxylum nitidum

目的:比较两面针根、茎的抗击打损伤和镇痛抗炎作用,为两面针以茎入药,扩大药用部位提供实验依据。方法:采用大鼠腿部击打损伤模型比较两面针根、茎的抗击打损伤作用,采用小鼠扭体模型和热板致痛模型比较两面针根、茎的镇痛作用,采用角叉菜胶致大鼠足肿胀模型、弗氏佐剂致大鼠足肿胀模型和大鼠棉球肉芽肿模型比较两面针根、茎的抗炎作用。结果:两面针根、茎均能不同程度改善大鼠腿部击打损伤部位的外观和组织学症状表现,减少醋酸致小鼠疼痛扭体次数和提高热板致小鼠疼痛痛阈值,抑制角叉菜胶致大鼠足肿胀和棉球致大鼠肉芽增生的炎症反应。结论:两面针茎抗击打损伤和镇痛抗炎的药效作用与两面针根相近。

Objective： To provide the scientific evidence for expansion of medicinal parts of Zanthoxylum nitidum by comparing the effects of anti-contusion injury,analgesia and anti-inflammation of its root and stem. Methods： The pharmacological effects between root and stem of Zanthoxylum nitidum were compared by observing the anti-injury effect in rats with injury struck by hammer. The analgesic effect in mice was evaluated by writhing test and hot plate test,and the anti-inflammatory effect on paw edema induced by carrageenan and granuloma induced by cotton pellet were investigated in rats. Results： Both root and stem of Zanthoxylum nitidum relieved the exterior and histological symptoms of rats＇ injury legs struck by hammer,decreased the numbers of mice＇s writhing,enhanced pain threshold of mice on heat plate,inhibited the edema of rats induced by carrageenan,and suppressed the granuloma of rats induced by cotton pellet. Conclusion： Stem of Zanthoxylum nitidum has similar effects of anti-contusion injury,analgesia and anti-inflammation with root of Zanthoxylum nitidum.