整合素与EGFR受体家族相互作用在乳腺癌中的作用研究进展

Progress in the Role of Integrin and EGFR Family Interaction in Breast Cancer

整合素与表皮生长因子受体(epithelial growth factor receptor,EGFR)在乳腺癌的发生、进展、侵袭与转移过程中发挥着重要的作用。在乳腺癌中,多种整合素的功能都与细胞的粘附相关,而EGFR与细胞增殖、转移密切相关,过表达的整合素和EGFR受体家族预示着预后不良。通过与受体结合,形成同源或异源二聚体,被活化的受体激活下游的信号蛋白,调节由细胞外至细胞内的信号途径,由此将刺激信号传入细胞内,从而控制细胞的增殖、转移等细胞生命事件,实现促进肿瘤进展与转移的作用。本文就整合素与EGFR之间的相互作用在乳腺癌中的作用、对乳腺癌治疗策略及新药研发方向的影响进行综述。

Both integrin and epidermal growth factor receptor（EGFR） are involved in the process of tumorigenesis, progression,invasion, and metastasis in breast cancer. The functions of various integrins in breast cancer have shown to be associated with tumor cell adhesion and overexpression of some integrins always play a critical role in tumor metastasis indicating poor prognosis. By ligand binding, activated integrin recruits signaling proteins downstream mediating the ＂outside-in＂signaling pathway which transduces extracellular stimulus into intracellular signals to regulate cell life events such as proliferation and migration. By banding specific ligand,two EGFRs form a homodimer or heterodimer complex. Overexpression of EGFR in breast cancer promotes the process of tumor progression and metastasis, which expects for poor prognosis. The functions of integrin and EGFR in breast cancer are revealed to be of vital importance respectively. This review discussed the crosstalk function between integrin and EGFR in breast cancer and the developments of new drug in the future for breast cancer.