3D打印模板引导125I粒子植入术前术后剂量对比

Dose comparison between pre and post operation of 125I seeds implantation guided by 3D print tamplate

目的比较3D打印模板引导粒子植入术前术后剂量差异，探讨其剂量的准确性。方法选取2015年8至11月于河北省人民医院实施3D打印模板引导粒子植入患者9例，术前手术体位固定患者扫描CT，行术前计划后打印3D模板，术中按模板预设针道位置穿刺肿瘤，扫描CT确定针尖位置无误后按术前计划植入粒子，术后行验证计划。观察手术前后的90％靶体积的最小吸收剂量（D90）、90％处方剂量覆盖的体积占靶体积的百分比（V90）、V100、V150及粒子数目有无差异。结果术前D90、V90、V100、V150及粒子数目分别为（7684±3279）eGy、93．2％±0．8％、89．8％±0．9％、62．8％±4．7％、（58±17）颗。术后1390、V90、V100、V150及粒子数目分别为（7531±3523）cGy、92．4％±2．0％、88．0％±2．5％、61．9％±5．3％、（56±17）颗。各指标手术前后比较差异均无统计学意义（均P〉0．05）。结论3D打印模板引导粒子植入术后剂量指标与术前比较无差别，对于比较固定的肿瘤，可能成为重复性好的标准术式。

Objective To compare the dose difference between pre and post operation of 125I seeds implantation guided by 3D print tamplate and investigate the dose accuracy. Methods From August 2015 to November 2015, a total of 9 patients were selected and underwent 3D print tamplate guided 125I seeds implantation in Hebei General Hospital. All patients had been fixed as the position of operation and then performed CT scan. After preplan was designed, the 3D tamplates were printed. The tumors were punctured through needles holes predesigned. Another CT scan was used to confirm the locations of needles and then seeds were implanted into tumor according to preplan. Postplan was performed after the operation. The D90, V90, V100, V150 and seeds number pre and post operation were collected and compared. Results The mean D90, V90, V100, V150 and seeds number preoperation was （7 684 ±3 279）cGy, 93.2% ±0. 8%, 89. 8% ±0. 9%, 62. 8%±4. 7% and 58 ± 17 respectively. The mean D90, V90, V100, V150 and seeds number postoperation was （7 531±3 523） cGy, 92.4% ±2.0%, 88.0% ±2. 5%, 61.9%±5.3% and 56± 17 respectively. The difference of all data between pre and post operation was not statistically significant （ all P 〉 0. 05 ）. Conclusions The dose parameters in postplan show no difference compared with preplan. For the fixed tumor, 3D print tamplate guided seeds implantation may become an easy repeated and standard procedure.