支架蛋白Gab的结构与功能及其在肿瘤、炎症和心血管疾病发生中的作用

Structure and function of the adapter protein Gab and its role in the development of tumor,inflammation and cardiovascular diseases

Gab家族蛋白(Grb2-associated binder family proteins)是生长因子受体结合蛋白2的结合蛋白。在哺乳动物中,Gab家族蛋白包括Gab1、Gab2和Gab3。该家族蛋白可通过介导膜受体与信号转导蛋白间的耦联及各信号分子间的相互作用参与信号转导,其主要是通过激活SHP2/RAS/ERK和PI3K/AKT两条经典的信号通路,进而参与一系列的生物应答。研究显示,Gab蛋白的表达或功能异常与肿瘤、炎症和心血管疾病的发生、发展密切相关。本文就Gab蛋白结构、参与信号转导的调节机制及其在肿瘤、炎症和心血管疾病发生、发展中的作用进行综述。

Gab proteins,Grb2（growth factor receptor binding protein 2）-associated binder,are important scaffolding adapter proteins required by many signaling pathways. In mammals,the Gab proteins mainly consist of Gab1,Gab2 and Gab3,and are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli,including various growth factors and cytokines. They are known to play key roles in many biological processes through the two classical signal pathways,SHP2/RAS/ERK and PI3K/AKT. In this review,we provide an overview of the structure and function of the scaffolding adapter,Gab,with a special focus on its role in tumor,inflammation and cardiovascular diseases.