哈尔滨地区糖化血红蛋白诊断糖尿病切点选择

Selection of Clinical Diagnostic Cut Point of Glycated Hemoglobin A1c in Harbin of China

目的本研究应用ROC曲线分析糖化血红蛋白(Hb A1c)在哈尔滨地区2型糖尿病中作为诊断标准的应用特点。方法通过口服75 g无水葡萄糖耐量试验,选取2型糖尿病患者712例,非糖尿病人为680例,并同时进行Hb A1c、人体测量及生化指标检测。分析并比较Hb A1c与FPG、2HPG之间的相关性,通过绘制ROC曲线确定Hb A1c诊断2型糖尿病的最佳切点。结果通过ROC曲线绘制及约登指数得到最佳切点为6.2%,其诊断2型糖尿病的灵敏度为80.2%,特异度为88.5%,曲线下面积为0.92。结论哈尔滨地区2型糖尿病患者其Hb A1c≥6.2为诊断糖尿病的最佳切点。

Objective To study the ROC curve analysis of glycated hemoglobin as a diagnostic standard of diabetes. Methods712 patients with diabetes,680 cases of normal glucose tolerance（ NGT） were collected by 75 g oral glucose tolerance test（ OGTT）. Hemoglobin A1 c and other indicators were measured at the same time. The correlation among Hb A1 c and other parameters monitored were analyzed. According to the receiver operating characteristic curve（ ROC curve）,the premium value of Hb A1 c for diagnosis of T2 DM was calculated. Results Hb A1 c cut- off 6. 2% or higher,as the diagnostic point of diabetes,had the specificity of0. 883,the sensitivity of 0. 802 and the AUC of（ 0. 92）. Conclusion Glycosylated hemoglobin can be used as one of the criteria for the diagnosis of type 2 diabetes in Harbin,China. Glycosylated hemoglobin in 6. 2% or more hadrthe best performance.