新生儿血液感染病原菌分布及其耐药性监测

Distribution and drug resistance of pathogenic bacteria in blood infection in newborns

目的研究新生儿血液感染病原菌的种类及其耐药情况,以指导临床合理选择抗菌药物。方法通过对某医院住院新生儿血标本培养和药敏试验,研究该医院住院新生儿血液感染病原菌分布和耐药状况。结果从1 240份新生儿血液标本中,共检出病原菌102株,检出率8.23%。检出革兰阳性菌83株,占81.37%,以凝固酶阴性葡萄球菌为主;其余为革兰阴性菌,占18.63%,以大肠埃希菌、肺炎克雷伯菌为主。血液标本分离的革兰阳性球菌对万古霉素和利奈唑胺高度敏感,而对青霉素G、氨苄西林、红霉素、苯唑西林等普遍耐药。分离的革兰阴性菌对氨苄西林敏感性较低。结论新生儿血液感染以革兰阳性球菌为主,对临床常用抗菌药物普遍耐药,仅对万古霉素和利奈唑胺敏感。

Objective To study the pathogenic bacteria and drug resistance of neonatal blood infection,in order to guide clinical rational choice of antibiotics. Methods The distribution and drug resistance of pathogenic bacteria in blood infection in the hospital were studied by means of culture and drug sensitivity test. Results From the blood samples of 1240 newborns,102 strains of pathogenic bacteria were detected and the detection rate was 8. 23%. 83 strains of gram positive bacteria were detected,those accounted for 81. 37% and were mainly Coagulase negative Staphylococci. The rest were gram negative bacteria,those accounted for 18. 63% and were mainly Escherichia coli,Klebsiella pneumoniae. Blood specimens were collected from the leather gram positive cocci and they were highly sensitive to Vancomycin and Linezolid,and were generally resistant to Penicillin G and Ampicillin,Erythromycin and Oxacillin. Gram negative bacteria isolated were low sensitive to Ampicillin. Conclusion Gram positive coccus are mainly in blood of neonates infection which are generally resistant to the clinical commonly used antimicrobial drugs and are sensitive only to Vancomycin and Linezolid.