巴马神酒对小鼠补肾壮阳作用实验研究

Experimental Study on Kidney-yang Reinforcing Effect of Bama Nectar

目的:观察巴马神酒对肾阳虚小鼠的影响,以及对正常小鼠交配能力及精子数量的影响。方法:观察巴马神酒对氢化可的松诱导的肾阳虚模型小鼠体重、体温、自主活动次数、耐寒能力、生殖器官脏器系数及抗脂质过氧化的影响,对去势性肾阳虚模型小鼠生殖器官脏器系数、免疫器官脏器系数及勃起功能的影响,以及对正常小鼠交配能力及附睾精子数量的影响。结果:巴马神酒能增加氢化可的松诱导的肾阳虚小鼠的体重、体温和自主活动次数,提高耐寒能力以及使精囊腺和前列腺、包皮腺、附睾的脏器指数上升,并提高血清中SOD含量和降低血清中MDA含量(与模型组比较,P<0.05或P<0.01);巴马神酒能使去势性肾阳虚小鼠的包皮腺及胸腺脏器系数有所提升,并缩短阴茎勃起潜伏时间(与模型组比较,P<0.05);巴马神酒能提高正常小鼠的交配能力和附睾精子数量(与空白组比较,P<0.05或P<0.01)。结论:巴马神酒具有一定的补肾壮阳作用。

Objective： To observe the effects of bama nectar in kidney-yang deficienct mice and on the mating ability and sperm counts of normal mice. Methods： The weight,body temperature,locomotor activity,cold-resistant,genital organ coefficient and lipid peroxidation of the hydrocortisone-induced kidney-yang deficient mice were detected. The genital organ ccoefficient,immune organ coefficient and erectile function of the ovariectomized mice were detected. The mating ability and the sperm counts of normal mice were measured. Results： Compared with the model group,bama nectar obviously increased the weight,body temperature and locomotor activity of the hydrocortisone-induced kidney-yang deficient mice,and improved the locomotor activity,the organ coefficient of seminal vesicle,prostate gland,preputial gland and epididymis. Furthermore,bama nectar significantly increased the SOD activity in serum and reduced the level of MDA in serum when compared with the model group（ P 〈0. 05 or P〈 0. 01）. Compared with the model group,bama nectar could increase the organ coefficient of foreskin and thymus gland in the ovariectomized mice,and shorten the erectile latency（ P 〈0. 05）. Compared with the normal group,bama nectar improved the mating ability and the sperm counts of the male mice（ P 〈0. 05 or P〈 0. 01）. Conclusion： Bama nectar has beneficial effects on invigorating kidney and strengthening yang.