健脾生血颗粒对气虚、脾虚型贫血模型小鼠的治疗效果

Curative effect of Jianpi Shengxue Granules on Spleen-deficient Anemia Mice

目的:探讨健脾生血颗粒对气虚、脾虚型贫血小鼠的治疗效果。方法:昆明鼠(SPF级)随机分为模型对照组、正常对照组、健脾生血组、浸膏组、硫酸亚铁组等5组。除正常对照组外,其余受试动物均皮下注射利血平建立脾气虚症小鼠模型。分别考察健脾生血颗粒对小鼠单核吞噬细胞功能、小鼠血清溶血素的影响以及对小鼠疏肝和胃功效的影响。结果:与其余各实验组相比,健脾生血组能显著提高小鼠的血清溶血素水平(P<0.05);对廓清指数作用显著(P<0.05),可提高吞噬活性(P<0.01),显著改善疏肝和胃模型小鼠的体质量和进食量(P<0.01)。结论:健脾生血颗粒能提高免疫水平,对于气虚脾虚型贫血中医模型小鼠具有显著的治疗效果,这对于临床使用健脾生血颗粒具有一定的参考价值。

Objective： To observe the effect of Jianpishengxue granules on deficiency of vital energy and spleen-deficient anemia mice. Methods： The kunming mice were randomly divided into 5 groups,such as model control group,control group,Jianpishengxue granule group,extract group and ferrous sulfate group. The spleen-deficient models for those mice except for control group were set up by subcutaneous injection resperpine. The effect of Jianpishengxue granule to clearance index,phagocytic activity and serum hemolysin of spleen-deficient anemia mice were investigated. Results： Compared with the model control group,Jianpishengxue granule could significantly enhance the level of serum hemolysin（ P 〈0. 05）,obviously increase the clearance index（ P 〈0. 05） and the phagocytic activity（ P 〈0. 05）. At the same time,Jianpishengxue granule could ease mental tension and irritability symptoms of spleen-deficient anemia mice. Extraction and ferrous sulfate showed the above similar results,but not as significant as Jianpishengxue granules. Conclusion： Jianpishengxue granules can remarkably enhance the immune function and possess significant effect on spleen- deficient anemia mice.