摘要
曲安奈德为肾上腺皮质激素,其抗炎和抗过敏作用起效快、较强且持久。但因其水溶性差、全身使用不良反应大等缺点使得研究者不断尝试对其进行剂型的改造和创新。本文综述国内外近年来报道的曲安奈德局部给药制剂的研究进展,包括固体制剂、乳剂、微粒分散体系以及其他研究较多的新剂型,为改善该药的生物利用度、提高用药安全提供更广泛的参考。
Triamcinolone acetonide is one of adrenocorticotropic hormones. Its anti-inflammatory and anti-allergic effects are strong and lasting. However,due to its poor water solubility and systemic side effects,researchers try to transform and create its new formula constantly. The paper reviewed the research progress in new formula of triamcinolone acetonide at home and abroad in recent years,including solid dosage forms,emulsion,particle dispersion system and the other new formula which have been researched in order to provide information for the improvement of bioavailability and safety.
出处
《中国药师》
CAS
2016年第3期559-562,共4页
China Pharmacist
关键词
曲安奈德
局部给药制剂
研究进展
Triamcinolone acetonide
Local administration preparations
Research progress
