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Linking lncRNA to genomic stability 被引量:1

Linking lncRNA to genomic stability
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摘要 Long Non-coding RNAs (lncRNAs), usually derived from intergenic regions or introns, play distinct and important roles in diverse biological processes. Up to now, many types of non-coding RNAs have been identified across spe- cies. They are highly heterogeneous in their lengths, struc- tures, and functions. Aberrant regulation of lncRNAs has been shown to be associated with human diseases, such as cancer, but the mechanisms have remained largely unknown (Rinn and Chang 2012). A recent study from Mendell and colleagues published in Cell dissected a novel pathway in which a specific IncRNA, termed NORAD, protects cells from becoming aneuploid (Lee et al., 2016), which is known to drive the occurrence and development of cancer, among other diseases. Long Non-coding RNAs(lnc RNAs),usually derived from intergenic regions or introns,play distinct and important roles in diverse biological processes.Up to now,many types of non-coding RNAs have been identified across spe-
作者 Hong Liu
出处 《Science China(Life Sciences)》 SCIE CAS CSCD 2016年第3期328-329,共2页 中国科学(生命科学英文版)
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