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中性粒细胞胞外诱捕网及其在相关疾病中的作用 被引量：2

Neutrophil Extracellular Traps and the Effects in Related Diseases
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摘要 中性粒细胞胞外诱捕网（NETs）是由激活的中性粒细胞释放到胞外的一种网状结构,不但可以包裹病原体,也具有很强的细胞毒性,与多种疾病的发病及进展密切相关.随着近年来对其代谢过程和影响因素的研究逐渐深入,NETs有望成为多种疾病诊断和治疗的新靶点. Neutrophil extracellular traps （NETs） are extracellular web-like structures released by activated neutrophils,which have a dual effect on the organisms.On one hand,NETs could trap pathogens leading to their clearance;on the other hand,NETs show strong cytotoxicities to human body and are closely related to the pathogenesis and progression of many diseases.With the comprehensive studies on the metabolism mechanisms and various influencing factors of NETs in recent years,NETs are suggested to be potential therapeutic target for the diagnosis and treatment of various diseases.
作者 朱明昂 曹清 莫茜
机构地区 上海交通大学医学院附属上海儿童医学中心卫生部儿童血液肿瘤重点实验室儿科转化医学研究所 上海交通大学医学院附属上海儿童医学中心感染科
出处 《国际免疫学杂志》 CAS 2016年第1期67-71,共5页 International Journal of Immunology
基金 基金项目：国家自然科学青年基金（81201450） 上海市科委启明星计划（14QA1402900）
关键词 中性粒细胞胞外诱捕网 细胞毒性 病理作用 肽酰基精氨酸脱亚胺酶 Neutrophil extracellular traps Cytotoxicity Disease pathogenesis Peptidylarginine deiminase
分类号 R363 [医药卫生—病理学]
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参考文献37

  • 1Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracel- lular traps kill bacteria [ J ]. Science, 2004,303 ( 5663 ) : 1532- 1535. DOI : 10.1126/science. 1092385.
  • 2张晓兰,宋英莉,朱辉.中性粒细胞胞外诱捕网的研究进展[J].国际免疫学杂志,2012,35(3):183-186. 被引量：5
  • 3Rodriguez-Espinosa O, Rojas-Espinosa O, Moreno-Ahamirano MM, et al. Metabolic requirements for neutrophil extracellular traps for- mation [ J ]. Immunology, 2015 , 145 ( 2 ) : 213 -224. DOI : 10. 1111 / imm. 12437.
  • 4Farrera C, Fadeel B. Macrophage clearance of neutrophil extracel- lular traps is a silent process[ J]. J Immunol,2013,191 (5) :2647- 2656. DOI: 10.4049/jimmunol. 1300436.
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  • 10Demers M,Wagner DD. NETosis:a new factor in tumor progres- sion and cancer-associated thrombosis [ J ] . Semin Thromb Hem- ost ,2014,40 ( 3 ) :277-283. DOI : 10.1055/s43034-1370765.

二级参考文献26

  • 1Segal AW. How neutrophils kilI microbes. Annu Rev Immunol, 2005, 23 : 197-223.
  • 2Brinkmann V, Reichard U, Goosmann C, et al, Neutrophil extra- cellular traps kill bacteria. Sc!ence, 2004, 303 ( 5663 ) : 1532- 1535.
  • 3Buchanan JT, Simpson AJ, Aziz RK, et al. DNase expression al- lows the pathogen group A Streptococcus to escape killing in neu- trophil extracellular traps. Curr Biol, 2006, 16(4) :396-400.
  • 4Urban CF, Reichard U, Brinkmann V, et al. Neutrophil extraeel- lular traps capture and kill Candida albieans yeast and hyphal forms. Cell Microbiol, 2006, 8(4):668-676.
  • 5Moon AF, Midon M, Meiss G, et al. Structural insights into cata- lytic and substrate binding mechanisms of the strategic EndA nu- clease from Streptococcus pneumoniae. Nucleic Acids Res, 201l, 39(7) :2943-2953.
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  • 7Hemmers S, Teijaro JR, Arandjelovic S, et al. PAIM-Mediated neutrophil extracellular trap formation is not required for immunity against influenza infection. PEoS ONE, 2011, 6(7) : 22043.
  • 8Lippolis JD, Reinhardt TA, Goff JP, et al. Neutrophil extracellu- lar trap formation by bovine neutrophils is not inhibited "by milk. Vet Immunol Immunopathol, 2006, 113 (1-2) :248-255.
  • 9Fuchs TA, Abed U, Goosmann C, et al. Novel cell death program leads to neutrophil extracellular traps. J Cell Biol, 2007, 176 (2) :231-241.
  • 10Brinkmann V, Zychlinsky A. Beneficial suicide : why neutrophils die to make NETs. Nat Rev Microbiol, 2007, 5(8) :577-582.

共引文献9

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国际免疫学杂志
2016年 第1期

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