高渗盐水雾化吸入治疗毛细支气管炎的疗效分析

Effect of nebulized hypertonic saline solution for bronchiolitis

目的:观察高渗盐水治疗毛细支气管炎的疗效。方法:采用随机、双盲、对照临床研究,将80例毛细支气管炎患儿分为观察组和对照组各40例,观察组雾化吸入3%氯化钠,对照组雾化吸入生理盐水+沙丁胺醇,每8 h 1次,比较两组患儿Lowell评分、肺部哮鸣音、湿罗音消失时间及住院时间。结果:观察组24、48、72 h Lowell评分显著低于对照组,差异有统计学意义;观察组肺部哮鸣音、湿罗音消失时间及住院时间显著低于对照组,差异有统计学意义;观察组及对照组均无明显不良反应。结论:雾化吸入高渗盐水治疗非重症毛细支气管炎安全、有效。

Objective： To study the effect of nebulized hypertonic saline solution in children with bronchiolitis. Methods： This was a double-blind randomized control clinical study. 80 children with bronchiolitis were divided randomly into two groups,40 cases in treatment group,and 40 cases in contrast group. Children in treatment group were given nebulized hypertonic saline solution,and in contrast group nebulized 0. 9% saline slution ＋ salbutamol,this therapy was repeated every 8 hours. The Lowell score,wheezing remission time,moist crackles disappearance time and days of hospitalization were compared between the two groups. Results： The Lowell score were lower in the treatment group compared to the contrast group in 24,48,72 hours after treatment,and the wheezing remission time and moist crackles disappearance time,days of hospitalization were also shorter. Children in two groups did not have side effect.Conclusion： The treatment of nebulized hypertonic saline solution in hospital children with mild to moderate bronchiolitis is effective and safe.