基于MRI健康成人丘脑的形态测量

Morphological study of the thalamus in health human on MRI

目的:探讨MRI丘脑与毗邻结构形态学变化规律和意义,为与丘脑形态改变相关的疾病提供线性测量指标方法:利用成人活体头部MRI扫描资料,观测丘脑及其毗邻结构,分析各线性指标与丘脑面积、丘脑体积的相关性。结果:在断层标本上采用单因素方差分析显示:丘脑矢径、丘脑宽、丘脑面积性差和侧差未见显著性差异;丘脑横径、丘脑长侧差未见显著性差异,但其性差差异性显著(P<0.05)。方差齐性检验后Pearson相关分析显示:丘脑长与壳横径、壳矢径、壳面积、尾状核头矢径成正相关,丘脑宽与尾状核头矢径负相关,丘脑矢径、丘脑长与侧脑室前角间距成负相关。在体积测量中标准化后各组样本采用单因素方差分析显示:丘脑体积、尾状核头横径、尾状核头矢径及壳矢径左、右侧差异显著(左侧>右侧,P<0.05),其余各数据无显著性差异。标准化后与丘脑体积相关程度最为密切的线性指标分别是丘脑横径、丘脑矢径、丘脑长、丘脑宽(正相关)。结论:丘脑毗邻结构参数与丘脑参数存在线性关系,其毗邻结构的形态变化可作为研究丘脑形态变化的参考指标,丘脑横径、丘脑矢径、丘脑长、丘脑宽可作为丘脑形态变化的初筛指标。

Objective： To explore the morphological variations and the relationship between the structures around the thalamus and the thalamus,and provide linear indices for thalamus morphological change-related diseases. Methods： Exploring the relationship between the structures around the thalamus and the thalamus. Results： On sectional images the gender difference and lateral difference are not significant on the area,the sagittal diameter and the width of the thalamus; the gender difference of the thalamus is significant whereas the lateral difference of the transverse diameter is not. The length of the thalamus is positively related to the sagittal diameter,the transverse diameter,the area of the putamen and the sagittal diameter of the caudate nucleus head（ P〈 0. 05）. The indice positively related to width of the thalamus is the sagittal diameter of the caudate nucleus head（ P〈 0. 05）. There is a negative relationship between the sagittal diameter of the caudate nucleus head and the width of the thalamus（ P〈 0. 05）. The distance between the anterior horns was negatively related to the sagittal diameter and the length of the thalamus（ P 〈0. 05）. After normalization,the lateral difference is significant on the volume of the thalamus,the sagittal diameter and sagittal diameter of the putamen,and transverse diameter of the caudate nucleus head（ left right,P〈 0. 05）. The indices which mostly related with the volume of the thalamus are the transverse diameter,the sagittal diameter,the length,the width of the thalamus. Conclusion： There is a linear relationship between the structures around the thalamus and the thalamus,the morphological changes of these structures could be used as linear indices to the thalamus. The transverse diameter,the sagittal diameter,the length,the width of the thalamus could be used as preliminary screening indices for morphological changes of the thalamus.