抗胆碱能药物索利那新和托特罗定治疗膀胱过度活动症的比较研究

Comparative study of anticholinergic drug solifenacin and toherodine in the treatment of overactive bladder

目的探讨抗胆碱能药物索利那新和托特罗定在治疗膀胱过度活动症(OAB)中的应用,比较其临床疗效。方法分析2010年3月至2015年4月天津市西青医院收治的68例膀胱过度活动症患者的临床资料,将其分为治疗组(36例)和对照组(32例),治疗组采用新型抗胆碱药物索利那新治疗,5 mg,1次/d,晚饭后口服;对照组采用托特罗定治疗,2 mg,2次/d,早晚饭后口服;比较两组患者治疗前后临床症状及不良反应发生情况。结果患者在给予索利那新治疗后,最大尿流率、残余尿量、日间排尿次数、急迫性尿失禁次数、夜尿次数较托特罗定明显改善,差异有统计学意义(P<0.05);治疗组膀胱过度活动症评分生活质量评分明显优于对照组。结论抗胆碱能药物索利那新在治疗膀胱过度活动症中的效果优于托特罗定,能够更好地改善OAB患者的临床症状,减少药物不良反应的发生。

Objective To investigate the application of anticholinergic drug solifenacin and Tottenham in the treatment of overactive bladder,and compare the clinical curative effect. Methods The clinical data of 68 patients with overactive bladder from March 2010 to April 2015 were analyzed,and the patients were divided into the treatment group（ 36 cases） and control group（ 32cases）. The treatment group was treated with new anticholinergic drugs solifenacin,5 mg,1 time / day,orally,after supper; The control group was treated with tolterodine,2 mg,2 times / day,orally,morning and evening. The clinical symptoms before and after treatment and the incidence of adverse reactions were compared between the two groups. Results Compared with control group,Qmax,residual urine volume,daytime frequency of urination,urgent urinary incontinence frequency,nocturia were significantly improved in treatment group,the differences were significant（ P〈0. 05）. The OABSS,QOL score of treatment group was significantly better than that of control group. Conclusion The effect of solifenacin on patients with overactive bladder is better than that of tolterodine,and can better improve OAB patients＇ clinical symptoms,reduce the occurrence of adverse drug reactions.