摘要
目的:明确银屑病患者皮肤CD103^+T细胞的表达及其与银屑病严重程度的关系。方法:免疫组化检测29例银屑病患者皮损和非皮损及6名健康对照皮肤中表皮及真皮CD103^+T细胞的表达。结果:CD103^+T细胞主要在真皮表达。银屑病患者皮损和非皮损真皮中每个高倍视野CD103^+T细胞百分率分别为(26.06±11.72)%和(12.82±4.50)%(P<0.05);健康人对照皮肤真皮内CD103^+T细胞百分率为(7.47±1.30)%,明显低于银屑病非皮损区(P<0.05)。银屑病患者皮损中,CD103^+T的表达与PASI值正相关(P<0.05)。结论:真皮中CD103^+T细胞可能与银屑病的发病及严重程度有关。
Objective： To detect the level of CD103~＋T lymphocytes in psoriatic lesions and to determine the relationship with the severity of psoriasis. Methods： CD103~＋T lymphocytes in dermis and epidermis of the lesions and non- lesional skin from 29 patients with psoriasis and skin from 6 healthy controls were detected by immunohistochemical staining. Results： CD103~＋T lymphocytes mainly distributed in dermis. The mean percentage of CD103~＋T lymphocytes in lesions,non- lesional skin and normal skin was（ 26. 06 ± 11. 72） %,（ 12. 82 ±4. 50） % and（ 7. 47 ±1. 30） % and there were significant differences among the groups（ P〈0. 05）.There was a positive correlation between the level of CD103~＋T lymphocytes and the PASI score（ P〈0. 05）.Conclusion： CD103~＋T lymphocytes in the dermis may associate with the occurrence and severity of psoriasis.
出处
《中国麻风皮肤病杂志》
2016年第2期70-73,共4页
China Journal of Leprosy and Skin Diseases
基金
卫生公益性行业科研专项经费项目(编号:201002016)
关键词
银屑病
CD103+T细胞
免疫组化
psoriasis
CD103＋T lymphocytes
immunohistochemical staining
