MTMR3基因1670C>T多态性与胃癌易感性的关系研究

Polymorphism of 1670C>T in MTMR3 is Associated with the Susceptibility to Gastric Cancer

目的：探讨MTMR3基因3＇非翻译区（3＇UTR）1670C〉T多态性与胃癌发病的关联。方法：通过病例对照研究,采用聚合酶链式反应-限制性片段长度多态性方法检测500例胃癌患者和502例正常对照者MTMR3基因1670C〉T位点的基因型,通过非条件Logistic回归,并校正了性别、年龄、吸烟、饮酒的影响,分析该位点与胃癌易感性的关系。结果：MTMR3基因1670C〉T基因型分布在病例组和对照组均符合Hardy-Weinberg平衡（P〉0.05）。经过年龄、性别、吸烟和饮酒状况校正的非条件logistic回归分析发现,与CC基因型患者相比,含有T等位基因的基因型（CT和TT）患者胃癌的发病风险增高（校正优势比=1.72,95%置信区间=1.36-2.16,P=3.99×10^-5）。结论：MTMR3基因1670C〉T多态性位点与胃癌发病存在显著性关联,1670T可能是胃癌发生的一个遗传危险因素。

Objective： To investigate the relationship between the polymorphism of 1670C〉T in 3＇-untranslated region （3＇UTR） of MTMR3 and gastric cancer （GC）. Methods： A case-control study was conducted. The genotypes of 1670C〉T in MTMR3 were identified with polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） in 500 GC cases and 502 cancer-free controls. Unconditional logistic regression, adjusted by gender, age, smoking and alcohol status, was used to analyze the association of genotypes with GC risk. Results： The genotypes of 1670C〉T in MTMR3 were in Hardy-Weinberg equilibrium in both controls and cases group（P〉 0.05）. After adjustment for age, gender, smoking status and alcohol consumption by logistic regression, the carriers ofT allele genotypes （CT and TT） of MTMR3 were associated with a significantly increased risk of GC （adjusted OR=1.72, 95% CI= 1.36-2.16, P=3.99×10^-5）, Compared with the CC wild type genotype carriers. Conclusions： The polymorphism of 1670C〉T in MTMR3 is associated with GC, thus the 1670T allele may be an inherited risk factor for GC development.