阿托伐他汀对急性心肌梗塞患者hs-CRP及血脂水平的影响

Influence of Atorvastatin on hs-CRP and Blood Lipid Levels in Patients with Acute Myocardial Infarction

目的:研究阿托伐他汀对急性心肌梗塞患者超敏C反应蛋白(hs-CRP)及血脂水平的影响。方法:选取2012年1月到2015年1月我院收治的急性心肌梗塞患者80例,按照随机数字表法将患者分为研究组和对照组,每组40例,对照组给予常规治疗,研究组在对照组的基础上给予阿托伐他汀治疗,比较治疗前后两组hs-CRP和总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平。结果:两组治疗后hs-CRP较治疗前显著降低(P<0.05),且研究组治疗后hs-CRP显著低于对照组,(P<0.05);治疗后两组TC、TG和LDL-C显著低于治疗前,HDL-C显著高于治疗前(P<0.05),且治疗后研究组TC、TG和LDL-C显著低于对照组,HDL-C显著高于对照组(P<0.05)。结论:阿托伐他汀治疗急性心肌梗塞具有较好的效果,能有效降低hs-CRP水平,改善患者血脂水平。

Objective： To study the influence of atorvastatin on hs-CRP and blood lipid levels in patients with acute myocardial infarction（AMI）. Methods： A total of 80 patients with AMI, who were admitted to Hainan People＇s Hospital from January 2012 to January2015, were randomly divided into study group（n=40） and control group（n=40）. The control group was received conventional treatment,on the basis of which, the study group was added atorvastatin. The levels of hs-CRP, total cholesterol（TC）, triglyceride（TG）, low density lipoprotein cholesterol（LDL-C） and high density lipoprotein cholesterol（HDL-C） of the two groups before and after treatment were compared. Results： Compared with before treatment, the levels of hs-CRP of two groups after treatment were significantly reduced（P〈0.05）, and the level of hs-CRP of study group after treatment was significantly lower than that of control group（P〈0.05）. The levels of TC,TG and LDL-C of two groups after treatment were significantly lower than before treatment, but HDL-C was significantly higher than before treatment. The levels of TC, TG and LDL-C of study group after treatment was significantly lower than those of control group, and the level of HDL-C was significantly higher than that of control group（P〈0.05）. Conclusion： Atorvastatin has a good effect in the treatment of patients with acute myocardial infarction, which can effectively reduce hs-CRP level and improve blood lipid level of the patients with AMI.