拉贝洛尔治疗妊娠期高血压疾病临床疗效及对分娩结局的影响

The clinical curative effect of labetalol in treatment of pregnancy hypertension and the influence on the outcome of delivery

目的探讨拉贝洛尔治疗妊娠期高血压疾病临床疗效及对分娩结局的影响。方法选择2013年7月至2015年7月收治的110例妊娠期高血压疾病患者作为研究对象，按照数字表法随机分为观察组和对照组，每组各55例，对照组采用常规方法进行治疗，观察组在对照组的基础上加用拉贝洛尔，比较两组患者临床疗效以及两组患者分娩结局情况。结果（1）治疗后观察组患者舒张压与收缩压分别为（67．95±4．87）mmHg、（134．62±11．82）mmHg均低于治疗前，差异均有统计学意义（t=7．435、9．224，均P〈0．05）；治疗后对照组患者舒张压与收缩压分别为（91．22±3．52）mmHg、（151．69±14．68）mmHg均低于治疗前，差异均有统计学意义（t=4．109、5．240，均P〈0．05）；治疗后两组舒张压与收缩压比较差异均有统计学意义（仁9．773、8．053，均P〈0．05）；（2）观察组患者新生儿阿氏评分为（9．33±0．76）分，显著高于对照组的（7．85±0．85）分，差异有统计学意义（t=5．108，P〈0．05）；观察组剖宫产、新生儿窒息、胎儿窘迫及产后出血发生率分别为43．64％、3．64％、5．45％、3．64％，均低于对照组，差异均有统计学意义（x2=8．942、19．057、14．122、16．936，均P〈0．05）。结论采用拉贝洛尔对妊娠期高血压疾病患者进行治疗，可显著降低患者血压水平及新生儿阿氏评分，改善产妇分娩结局，值得临床推广。

Objective To investigate the clinical effect of labetalol in treatment of pregnancy hypertension and the influence on the outcome of delivery. Methods 110 patients with pregnancy hypertension from July 2013 to July 2015 in Boai Hospital were selected as the research subjects,and they were randomly divided into observation group and control group,55 cases in each group. The control group was treated with conventional treatment,while the observation group was given labetalol on the basis of the control group. The clinical curative effect, birth outcomes were compared between the two groups. Results （ 1 ） After treatment, the diastolic blood pressure and systolic pressure in the observation group were （ 67.95 ± 4.87 ） mmHg and （ 134.62 ±11.82 ） mmHg, which were lower than pre - treat- ment,the differences were statistically significant （t = 7. 435,9. 224, all P 〈 0.05 ）. Those in the control group after treatment were （91.22 ± 3.52） mmHg and （ 151.69± 14.68） mmHg,which were significantly lower than before treat- ment （ t = 4. 109,5. 240, all P 〈 0.05 ）, the differences between the two groups after treatment were statistically signif- icant （ P 〈 0.05 ）. （2） Neonatal Apgar score of the observation group was （ 9.33 ± 0.76） points, which was signifi- cantly higher than （7.85±0.85 ） of the control group, the difference was statistically significant （t = 5. 108, P 〈 0. 05 ）. The incidence rates of cesarean section, neonatal asphyxia, fetal distress and postpartum hemorrhage of the ob- servation group were 43.64% , 3.64%, 5.45% , 3.64%, which were significantly lower than the control group, the differences were statistically significant （ X2 = 8. 942,19. 057,14. 122,16. 936, all P 〈 0.05 ）. Conclusion The use of labetalol in treatment of patients with hypertension of pregnancy can significantly reduce the blood pressure level and birth~ score,improve maternal birth outcomes,which is worth clinical promotion.