中西医结合治疗雷诺综合征的疗效观察

Therapeutic effect of integrated traditional Chinese and western medicine therapy on reynolds syndrome

目的观察中西医结合疗法治疗雷诺综合征的疗效。方法104例雷诺综合征患者被采用随机数字表法随机分为观察组59例和对照组45例，观察组采用硝苯地平、阿司匹林联合中医辨证施治治疗，对照组仅采用硝苯地平、阿司匹林治疗。治疗前和治疗1个疗程后测试冷水试验、握拳试验结果和血液流变学指标；在治疗1个疗程之后评价两组的治疗效果。结果观察组治疗后的握拳试验、冷水试验阳性率为32．2％,23．7％，均低于对照组的75．6％、57．8％（x2=19．199、12．504，P〈0．05）。两组治疗后的血浆黏度（1．25±0．11）mPa／s、红细胞聚集指数（2．04±0．29）、红细胞刚性指数（4．20±0．58）均低于治疗前（1．49±0．13）mPa／s、（2．27±0．30）、（4．67±0．59），红细胞变形指数（1．38±0．26）均高于治疗前（1．21±0．28）（t=2．704、1．127、9．200、1．687、12．898、5．200、12．613、5．323，均P〈0．05）；观察组治疗后的血浆黏度、红细胞聚集指数、红细胞刚性指数均低于对照组，红细胞变形指数均高于对照组（t=10．187、3．948、3，195、4．172，均P〈0．05）。观察组的总有效率89．8％（53／59），高于对照组的71．1％（32／45），差异有统计学意义（x2=5．991，P〈0．05）。观察组的药物不良反应发生率10．2％（6／59），对照组的药物不良反应发生率11．1％（5／45），差异无统计学意义（x2=0．024，P〉0．05）。结论在治疗雷诺综合征中，中西医结合疗法具有更好的疗效，药物不良反应发生率较低，具有良好的临床应用价值。

Objective To explore therapeutic effect of integrated traditional Chinese and western medicine therapy on reynolds syndrome, and to provide effective and reliable operation method for treatment of the disease. Methods 104 cases with reynolds syndrome were randomly divided into observation group （59 cases） and control group （45 cases） by random number table method. The observation group was treated with aspirin, nifedipine combined with traditional Chinese medicine dialectical therapy,the control group was treated with aspirin and nifedipine. The cold water test , fist test results and hemorheology indexes of the two groups were measured before and after a period of treatment. The therapeutic effects were evaluated after one course. Results After treatment, the fist test, cold water test positive rates of observation group were 32.2% ,23.7% ,which were lower than 75.6% ,57.8% of the control group （X2 = 19. 199,12. 504, all P 〈 0. 05）. The plasma viscosity （ 1.25 ±0. 11 ） mPa s, erythrocyte aggregation index （2.04 ± 0.29 ）, erythrocyte rigidity index （4.20 ± 0.58 ） of the two groups were lower than those before treatment （1.49 ±0.13）mPa s, （2.27 ±0.30）, （4.67 ±0.59） ,and the deformation index of red blood cell （ 1.38 ± 0.26） was higher than before treatment （ 1.21 ± 0.28 ） （ t = 2. 704,1. 127,9. 200,1. 687,12. 898,5. 200, 12. 613,5. 323, all P 〈 0. 05 ）. After treatment, the plasma viscosity, erythrocyte aggregation index and rigidity index of red blood cells were lower than those in the control group, and the deformation index of red blood cells was higher than the control group （t = 10. 187,3. 948,3. 195,4. 172, all P 〈 O. 05 ）. The total effective rate of the observation group was 89.8% （53/59）, which was higher than 71. 1% （32/45）of the control group, the difference was statistically significant （ X2 = 5. 991 ,P 〈 0.05 ）. Drug adverse reaction rate of the observation group was 10.2% （6/59）, that of the control group was 11. 1% （ 5/45 ）, the difference was not statistically significant （ X2 = 0. 024, P 〉 0. 05 ）. Conclusion In the treatment of reynolds syndrome,the integrated traditional Chinese and western medicine therapy has better curative effect and low drug adverse reaction rate,with good clinical application value.