肾上腺糖皮质激素节律性分泌及主要受控因素

Rhythmic Secretion and Main Control Factors of Adrenal Glucocorticoid

机体在维持内环境稳态和适应外环境的过程中,各种生理机能和代谢活动按照一定的时间顺序发生周而复始的节律变化,称为生物节律。肾上腺糖皮质激素作为机体内维持稳态的一种核心内分泌激素,在维持机体内生命活动发生和营养物质代谢的有序性方面扮演着重要角色。自然状态下,外源受控因素(食物和光照等)通过丘脑的视交叉上核和生物钟之间的复杂的同步反馈调控,使肾上腺糖皮质激素的产生、分泌及生物学作用都具有了节律性特征。本文主要就糖皮质激素的合成、分泌及其内在作用机制的节律性变化特点等方面进行综述,以期为机体内生物节律机制的研究及其对动物生产的指导提供参考。

Biological rhythms are universal phenomena in live organisms,the variations of the timing and duration of physiological functions and biological activities occur,to maintain the internal homeostasis and adapt the external environment. As a pivotal endocrine hormone,adrenal glucocorticoid plays an important role in keeping physical activities and nutrient metabolisms on track orderly. In natural environment,exogenous control factors such as food and light rhythmically regulate the synthesis,secretion and biological effects by complex feedback regulation betw een suprachiasmatic nucleus in thalamus and biological clocks. This paper mainly reviewed the rhythmical characteristics of synthesis,secretion and internal mechanism of adrenal glucocorticoid,to provide mammal biological rhythms regulation mechanism with its potential use in animal production.