神经肽Y的促摄食作用及其调控机制

The Orexigenic Role and Mechanism of Neuropeptide Y

神经肽Y（NPY）是一种广泛存在于中枢和外周并维持内环境稳态的神经递质,其在机体摄食调控中起着主要作用。NPY神经元主要位于下丘脑弓状核（ARC）,由其发出的纤维投射到达下丘脑室旁核（PVN）、腹内侧核（VMN）、外侧区（LHA）、背内侧核（DMN）等核团,通过NPY神经纤维与对应的受体形成突触,从而发挥促摄食调控作用。NPY受体是Gi/Go-蛋白偶联受体,有Y1~Y8 8个亚型受体,其中Y1受体在下丘脑能量代谢调控中发挥着主导作用。本文对NPY的结构以及ARC、PVN、VMN、LHA、DMN核团中NPY相关的摄食调控作用及其分子机制进行了阐述,旨在为相关研究提供基础资料。

Neuropeptide Y（ NPY） is a neurotransmitter widely spread in central and peripheral nervous system for sustaining homeostasis. The prominent role for NPY is its regulation of food intake. NPY neurons are mainly localized in arcuate nucleus（ ARC） of hypothalamus. The projection of these neurons mainly reach paraventricular nucleus（ PVN）,ventromedial nucleus（ VMN）,lateral hypothalamic area（ LHA） and dorsomedial nucleus（ DMN） of hypothalamus forming synaptic connection and further regulate food intake. NPY receptors are Gi / Go-protein coupled receptors including Y1 to Y8 8 kinds of subtypes. Y1 receptor plays a major role in the regulation of energy metabolism. This article review s the structure of NPY and its role of regulating food intake in ARC,PVN,VMN,LHA and DMN providing basic material for relative research.