介入化疗联合放疗治疗脑转移癌的近期疗效观察

Combined Therapy of Interventional Chemotherapy with Radiotherapy for the Treatment of Cerebral Metastatic Carcinoma

目的分析介入化疗联合放疗治疗脑转移癌的临床疗效。方法分析2011年4月~2012年10月治疗的脑转移癌患者64例的临床资料,按照1∶1原则随机将患者分为观察组与对照组各32例,观察组给予经股动脉穿刺颈内动脉灌注化疗联合放疗疗法,对照组单纯给予放疗,比较两组患者的治疗效果。结果脑转移病灶的临床近期疗效评价于放疗结束后3个月进行,观察组与对照组的总有效率分别为78.13%、56.25%,差异有统计学意义（P〈0.05）;观察组不良反应发生率为37.50%（12/32）,对照组不良反应发生率为34.38%（11/32）,两组不良反应发生率比较差异不显著（P〉0.05）。结论介入化疗联合放疗能提高脑转移癌的颅内局部控制,提高了患者的生活质量。

Objective To observe the clinical effects of interventional chemotherapy with radiotherapy for the treatment of cerebral metastatic carcinoma. Methods The clinical data of 64 patients who underwent cerebral metastatic carcinoma in our hospital during April 2011 and October2012 were collected,the whole patients were randomly divided into an observation group and a control group,each group contained 32 cases. The observation group was given interventional chemotherapy with radiotherapy,the control group was only given radiotherapy. Results The total effective rate in the observation group（ 78. 13%） was significantly higher than in control group（ 56. 25%）（ P〈0. 05）; The incidence of adverse reactions in the observation group and control group were37. 50%（ 12 /32）,34. 38%（ 11 /32）,there were no significant differences between the two groups（ P〈0. 05）. Conclusions Interventional chemotherapy with radiotherapy can increase the local control rate of cerebral metastatic carcinoma and benefit the life quality for patients.