黄芪注射液对2型糖尿病患者尿微量白蛋白的影响探讨

Effect of Astragalus Injection on Urinary Albumin in Patients with Type 2 Diabetes Mellitus

目的观察黄芪注射液应用于2型糖尿病患者后临床症状和尿微量蛋白变化情况。方法选择该院内科病房2014年3月—2015年6月收治的2型糖尿病患者86例,依据随机分组表划分为实验组和对照组各43例,其中对照组给予常规降糖药物和缬沙坦降压治疗,实验组在此基础联合使用黄芪注射液,评估两种患者临床疗效。结果研究显示实验组治疗有效率为95.35%,对照组治疗有效率为83.72%,两种数据比较差异具有统计学意义(P<0.05)。实验组治疗后疲倦乏力、腰膝酸软、肢体麻木、下肢浮肿、尿频尿急、面色晦暗、脉象搏动紊乱、舌苔舌质的中医临床症状积分均明显超过对照组,且差异有统计学意义(P<0.05)。实验组患者治疗后空腹血糖、尿微量白蛋白水平均较对照组有明显降低,且差异有统计学意义(P<0.05)。结论黄芪注射液能够改善2型糖尿病患者临床症状、空腹血糖及尿微量白蛋白水平,提高临床治疗效果,值得临床借鉴。

Objective To observe the clinical symptoms and changes of urine protein in patients with type 2 diabetes mellitus. Methods Patients with type 86 diabetes in our hospital from March 2014 to June 2015 were divided into experimental group and control group, 43 cases in control group. The experimental group was treated with astragalus injection and the clinical efficacy was evaluated in two patients. Results The effective rate of the treatment group was 95.35%, the effective rate was 83.72% in the control group, the difference was statistically significant（P〈0.05） between the two groups. Experimental group after treatment, fatigue, Yaoxisuanruan, numbness of limbs, edema of lower limbs, urinary frequency and urgency, complexion dark and gloomy, pulse beating disorders, tongue of TCM clinical symptom score were significantly more than the control group, and the difference is significant（P 0.05）. The fasting blood glucose and urine trace albumin levels in the experimental group were significantly lower than those in the control group, and the difference was statistically significant（P〈0.05）. Conclusion Astragalus injection can improve the clinical symptoms, fasting blood glucose and urine albumin level in patients with type 2 diabetes, and improve the clinical treatment effect, it is worthy of clinical reference.