乙型肝炎三个抗原抗体系统的联合检测及HBsAg动态观察

Observation on the three antigen-antibody systems of hepatitis B

乙型病毒性肝炎流行广泛,发病率高,目前各地关于乙肝的研究,报告甚多。本文仅就乙肝的三个抗原抗体系统的检测及HBsAg的动态改变,综合报告如下。 资料来源 本文病例均系1982～1983年传染病院收治的肝炎病人,均按1978年杭州全国肝炎会议所制定的病毒性肝炎诊断标准进行确诊。

The observation of HBsAg .and the detection of the three antigen-antibody systems of hepatitis B (HB) are described in this paper.Detection of the three antigen-antibody systems of HB in 148 cases at our department showed that Anti-HBc was the most sensitive in the diagnosis of HB, the positive rate being almost the same as that of HBsAg. Therefore, it is suggested that the detection of Anti-HBc be included in the diagnosis of HB. Besides, the HBV carriers recognized by the detection of Anti-HBc were much higher than those detected by HBsAg alone, and its positive rate was also much higher than that of HBeAg. We conclude thai its diagnostic and epideraiological significance is much greater than that of the other two antigen-antibody systems.Our observation of 381 HB inpatients showed that of the 77.8% of the parents who had recovered from acute HB their HBsAg became negative in 56.45%when they were discharged, and that of the 22.2% of those who had not recovered from the disease their HBsAg remained positive in 71.7%. However,in patients with chronic hepatitis their HBsAg remained positive in 84.85% of those who had recovered from the disease and in 78.9% of those who had not recovered from the disease.The results indicate that the rate of HBsAg carriers is higher in chronic hepatitis than that in acute hepatitis no matter whether the patients have recovered from the disease or not.Our study of the relationship between icteric index and HBsAg titer in 139 patients of acute and chronic HB suggests no correlation of the degree of liver function insuffcieincy to the rate of HBsAg becoming negative. In patients with acute hepatitis all their HBsAg became negative in no more than 6 months and in most of the cases it became negative in the first or the second month, but in chronic hepatitis it took longer period for HBsAg to become negative.