腹腔镜术后应用醋酸曲普瑞林治疗子宫内膜异位症的临床观察

Clinical Observation of Triptorelin Acetate in the Treatment of Endometriosis after Laparoscopy

目的:观察腹腔镜术后应用醋酸曲普瑞林治疗子宫内膜异位症的临床疗效与安全性。方法:196例子宫内膜异位症患者按入院先后顺序随机分为试验组和对照组,各98例。两组患者均采取腹腔镜手术治疗,术后试验组患者给予醋酸曲普瑞林肌内注射,每次3.75 mg,每4周1次;对照组患者给予孕三烯酮口服,每次2.5 mg,每周2次,疗程均为5个月。观察两组患者的排卵、月经恢复时间及不良反应发生情况;随访1年,观察两组患者的复发情况。结果:治疗后,试验组患者的排卵和月经恢复时间均显著短于对照组,差异具有统计学意义(P<0.05)。试验组患者的不良反应发生率(17.34%)显著低于对照组(35.71%),差异具有统计学意义(P<0.05)。随访期间,试验组患者的复发率(7.14%)显著低于对照组(18.37%),差异具有统计学意义(P<0.05)。结论:腹腔镜术后应用醋酸曲普瑞林能够显著提高子宫内膜异位症的治疗效果,减少不良反应的发生。

OBJECTIVE：To observe clinical efficacy and safety of triptorelin acetate in the treatment of endometriosis after laparoscopy. METHODS：196 cases of endometriosis were randomly divided into experimental group and control group with 98 cases in each group according to admission sequence. Both groups received laparoscopic surgery. After surgery,experimental group was given triptorelin acetate by intramuscular injection,3.75 mg/time,every 4 weeks;control group was given gestrinone orally,2.5mg/time,twice a week,for 5 months. The ovulation,menstrual recovery and the occurrence of ADR were observed in 2 groups.The endometriosis relapse of 2 groups were followed up for 1 year and observed. RESULTS：After treatment,the ovulation recovery time and menstrual recovery time of experimental group were all shorter than those of control group,with statistical significance（P〈0.05）. The incidence of ADR in experimental group（17.34%）was significantly lower than in control group（35.71%）,with statistical significance（P〈0.05）. During follow-up period,the relapse rate of experimental group（7.14%）was significantly lower than that of control group（18.37%）,with statistical significance（P〈0.05）. CONCLUSIONS：After laparoscopic surgery,triptorelin acetate can significantly improve therapeutic efficacy of endometriosis,reduce the occurrence of ADR.