体外震波碎石术后应用中药排石汤治疗肾结石患者的疗效观察

Efficacy Observation of Extracorporeal Shock Wave Lithotripsy Combined Use Paishi Decoction in the Treatment of Kidney Stone

目的:观察体外震波碎石术后应用中药排石汤治疗肾结石患者的临床疗效。方法:选择肾结石患者160例,按随机数字表法分为观察组和对照组,各80例。对照组患者采用HB-ESWL-VG型体外冲击波碎石机行体外震波碎石。观察组患者在对照组基础上给予中药排石汤300 ml,tid,连续治疗1周。观察两组患者临床疗效及治疗前后血清炎性因子白细胞介素(IL)-2、IL-6、肿瘤坏死因子α(TNF-α)水平,T细胞亚群CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平,红细胞免疫功能指标C3b受体花环(C3b RR)、免疫复合物花环(ICR)、肿瘤红细胞花环(TER)水平。结果:观察组患者有效率(98.75%)明显高于对照组(91.25%),差异有统计学意义(P<0.05);治疗后,观察组患者IL-2、IL-6、TNF-α水平明显低于对照组,CD3^+、CD4^+、CD4^+/CD8^+、C3b RR、ICR、TER水平明显高于对照组,差异有统计学意义(P<0.05);两组患者CD8^+比较,差异无统计学意义(P>0.05)。结论:体外震波碎石联合中药排石汤能明显减轻肾结石患者炎症反应,增强红细胞免疫功能,提高治疗效果。

OBJECTIVE：To observe clinical efficacy of extracorporeal shock wave lithotripsy combined with Paishi decoction in the treatment of kidney stone. METHODS：160 patients with kidney stone were selected and randomly divided into observation group and control group,with 80 cases in each group. Control group only received HB-ESWL-VG extracorporeal shock wave lithotripsy;observation group additionally received Paishi decoction 300 ml,tid,for consecutive 1 week,on the basis of control group.Clinical efficacy was observed in 2 groups;the levels of serum inflammatory factor IL-2,IL-6,TNF-α,T lymphocyte subset CD3^＋,CD4^＋,CD8^＋and CD4^＋/CD8^＋,erythrocyte immune function indicator C3 b receptor rosette（C3b RR）,immunity complex rosette（ICR）and tumor erythrocyte rosette（TER）level were detected in 2 groups before and after treatment. RESULTS：The effective rate of observation group（98.75%）was significantly higher than that of control group（91.25%）,with statistical significance（P〈0.05）. After treatment,the levels of IL-2,IL-6 and TNF-α in observation group was significantly lower than in control group,the levels of CD3^＋,CD4^＋,CD4^＋/CD8^＋,C3 b RR,ICR and TER were significantly higher than control group,with statistical significance（P〈0.05）. Comparsion of CD8^＋between 2 groups was not statistically significant（P〈0.05）. CONCLUSIONS：The extracorporeal shock wave lithotripsy combined with Paishi decoction can relieve inflammation reaction,enhance immune function and improve therapeutic efficacy.