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EGCG对肾缺血再灌注损伤的保护作用及其作用机制的研究 被引量：3

The Investigation of the Protection Effects and Mechanism of EGCG on Kidney Ischemia Reperfusion Injury
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摘要 探讨了表没食子儿茶素没食子酸酯(EGCG)对大鼠肾缺血再灌注损伤的保护作用及其机制。结果表明,与肾缺血再灌注损伤模型组相比,EGCG组肾功能改善,肾组织病理改变,Wnt3a、?-catenin、p53、p21、MDA、IL-6、IFN-?和TNF-?表达明显减少,而CAT,GPX和SOD表达明显增加。说明EGCG预处理减轻肾缺血再灌注损伤与抑制Wnt3a/?-catenin/p53信号通路介导的炎症反应和氧化应激相关。 The study aims to investigate potential protection and mechanism of epigallocatechin gallate(EGCG) on kidney ischemia reperfusion injury. The results showed that EGCG treatment improved renal dysfuction, pathlogical change of kidney tissues, and reduced the expression of Wnt3a, β-catenin, MDA, IL-6, IFN-γ and TNF-α, but increased the levels of CAT, GPX and SOD, suggesting that EGCG can protect the kidney from ischemia-reperfusion injury in rats which is associated with suppressing the activation of Wnt/β-catenin/p53 signaling pathway and inhibiting inflammation and oxidative stress.
作者 刘洪国
机构地区 潍坊医学院人体解剖学教研室
出处 《茶叶科学》 CAS CSCD 北大核心 2016年第2期169-174,共6页 Journal of Tea Science
关键词 表没食子儿茶素没食子酸酯 肾缺血再灌注损伤 炎症 氧化应激 Wnt/B-catenin EGCG kidney ischemia reperfusion injury inflammation oxidative stress Wnt/B-catenin
分类号 R692 [医药卫生—泌尿科学]
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参考文献15

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同被引文献63

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茶叶科学
2016年 第2期

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