草木樨流浸液片联合督灸治疗强直性脊柱炎的临床观察

Clinical observation of Melilotus Extract Tablets combined with Dujiu for treating ankylosing spondylitis

目的观察草木樨流浸液片(MET)联合督灸对强直性脊柱炎(AS)患者的临床疗效及对血清T淋巴细胞亚群的影响,探讨草木樨流浸液片对强直性脊柱炎的药理作用机制。方法将40例符合标准的HLA-B27阳性强直性脊柱炎患者随机分为两组,试验组给予草木樨流浸液片联合督灸治疗,对照组给予双氯芬酸钠片,分别于治疗前及治疗4周后评估患者病情活动性,采用流式细胞仪检测患者血清T淋巴细胞亚群水平。结果 1治疗前,两组患者血沉、C反应蛋白差异无统计学意义(P>0.05);T淋巴细胞亚群水平差异无统计学意义(P>0.05);2治疗4周后,受试者病情明显改善,试验组有效率高于对照组;草木樨流浸液片联合督灸组胃肠道不良反应发生率(0/20)低于对照组(4/20);T淋巴细胞亚群CD3^+、CD4^+水平高于对照组(P<0.05)。结论草木樨流浸液片联合督灸能够纠正强直性脊柱炎患者淋巴细胞亚群亚群紊乱,从而发挥临床疗效。

Objective To investigate the effect of Melilotus Extract Tablets (MET)with DuJiu on inflammatory cyto-kines (TNF -α,IL -2,IL -6)in ankylosing spondylitis with positive HLA -B27,and explore it′s mechanism of clinical efficacy.Methods 40 AS patients with positive HLA -B27 were randomly divided into two groups:treatment group re-ceived MET,control group received diclofenac.Clinical manifestation and disease activities index were recorded,serum lev-els of T lymphocyte were determined by using Flow Cytometry method in the patients of AS.Results There were no signifi-cant difference before therapy between the two groups(P >0.05)in CRP and ESR and the T lymphocyte,after 4 weeks treatment,all patients had obviously improvement in CRP and ESR,there were no significant difference between the two groups of the number of adverse drug reactions (ADRs)after 4 weeks treatment,but the gastrointestinal tract ADRs in Met group was lower than the diclofenac group(P <0.05).Comparing the index of inflammatory factors of two groups,the Met group′s was better than the diclofenac group′s,the improvement of CD3 + and CD4 + between the two groups were significant differernce(P <0.05).Conclusion The clinical efficacy of Melilotus Extract Tablets with Dujiu was significant,the mech-anism may relevant with regulating the levels of T lymphocyte.