咖啡因对子宫内膜癌化疗增效作用的临床研究

The enhancing effects of caffeine on endometrial carcinoma chemotherapy

目的:研究分析咖啡因对子宫内膜癌化疗的增效作用。方法:经筛选我院86例子宫内膜癌患者作为研究对象,随机分为两组,术前采用紫杉醇联合顺铂二联化疗方法进行治疗,分别测定其治疗前后辅以或不辅以咖啡因子宫内膜组织雌激素受体(ER)、孕激素受体(PR)及p21的蛋白表达水平,以及血清CA-125水平。结果:治疗后,患者ER、PR蛋白表达水平降低,p21蛋白表达增高,血清CA-125水平增高,与治疗前相比差异有统计学意义(P<0.05)。辅以咖啡因治疗的患者与不辅以咖啡因治疗的患者相比,ER、PR、p21蛋白表达及血清CA-125水平改变更明显,差异有统计学意义(P<0.05)。结论:咖啡因对紫杉醇联合顺铂二联化疗方法治疗子宫内膜癌有增效作用。

Objectives： To study the enhancing effect of caffeine on endometrial carcinoma chemotherapy.Methods： After screening,86 cases of endometrial carcinoma were selected as research objects and randomly divided into 2 groups. Before the operation,chemotherapy method of paclitaxel combined with cisplatin was used to determine whether the patients were treated with or without caffeine. The protein expression of estrogen receptor（ ER）,progesterone receptor（ PR） and p21 and CA- 125 Serum level were tested before and after the treatment.Results： After the treatment,the levels of ER and PR protein expression decreased,p21 protein expression increased and CA- 125 serum level increased,all with statistically significant difference compared with these before treatment（ P〈0. 05）. Compared with patients treated without caffeine,the changes in PR,ER,p21 protein expression and CA- 125 serum level were more obvious in patients treated with caffeine,and the difference was statistically significant（ P〈0. 05）. Conclusion： Caffeine exerts enhancing effects on chemotherapy treatment of endometrial carcinoma.