复发性尖锐湿疣患者人乳头瘤病毒感染模式和细胞免疫功能的分析

Infection patterns and cellular immune function of patients with recurrent genital warts HPV

目的:探讨复发性尖锐湿疣患者HPV感染模式和细胞免疫功能。方法:对2010年1月到2013年10月我院收治的131例尖锐湿疣患者的临床资料进行回顾性分析,根据患者进行治疗后是否复发分为治愈组和复发组。分析两组患者HPV感染亚型以及患者外周血T淋巴细胞亚群的情况与尖锐湿疣患者治疗后复发的关联。结果:治愈组尖锐湿疣患者HPV感染亚型高危型15例(28.85%),低危型37例(71.15%);复发组尖锐湿疣患者HPV感染亚型高危型52例(65.82%),低危型27例(34.18%)。两组尖锐湿疣患者HPV感染亚型比较,差异具有统计学意义(P<0.05)。治愈组52例,CD3+总T细胞、CD4+辅助性T细胞、CD8+细胞毒T细胞分别占(74.83±8.07)%、(38.92±4.22)%、(31.46±5.43)%,CD4+/CD8+比值为(1.31±0.25);复发组79例,CD3+总T细胞、CD4+辅助性T细胞、CD8+细胞毒T细胞分别占(67.62±8.65)%、(33.67±4.56)%、(39.63±4.27)%,CD4+/CD8+比值为(0.94±0.33)。两组尖锐湿疣患者外周血T淋巴细胞亚群比较,差异具有统计学意义(P<0.05)。结论:尖锐湿疣患者治疗后复发与患者HPV感染亚型以及外周血T淋巴细胞亚群免疫功能异常紧密相关。

Objectives： To investigate the infection patterns and cellular immune function of patients with recurrent genital warts HPV. Methods： Clinical data of 131 patients with genital warts treated in our hospital from January 2010 to October 2013 were analyzed retrospectively. They were divided into cure group and recurrent group.Sub types of HPV infection and the relationship between circumstances of T lymphocyte subset sand relapse were analyzed. Results： There were 15 cases（ 28. 85%） of high- risk and 37 cases（ 71. 15%） of low- risk HPV sub type infection in cure group; there were 52 cases（ 65. 82%） of high- risk and 27 cases（ 34. 18%） of low- risk HPV sub type infection in recurrent group. The difference was statistically significant（ P〈0. 05）. Among the 52 cases in cure group,CD3＋total T cells,CD4＋helper T cells,CD8＋cytotoxic T cells accounted for（ 74. 83 ±8. 07） %,（ 38. 92 ± 4. 22） % and（ 31. 46 ± 5. 43） %,respectively. CD4＋/ CD8＋equaled to（ 1. 31 ±0. 25）; among 79 cases in recurrent group,CD3＋total T cells,CD4＋helper T cells,CD8＋cytotoxic T cells accounted for（ 67. 62 ± 8. 65） %,（ 33. 67 ± 4. 56） %,and（ 39. 63 ± 4. 27） %,respectively. CD4＋/ CD8＋equaled to（ 0. 94 ± 0. 33）. The difference was statistically significant（ P〈0. 05）. Conclusion： The relapse of genital warts and sub types of T lymphocyte subsets and immune dysfunction are closely related.