重组干扰素α-2b栓在高危型人乳头瘤病毒感染宫颈上皮内瘤变患者行宫颈环形电切术后的应用

Application of recombinant interferon α-2b bolt on patients with high-risk human papilloma virus (hr-hpv) infected with cervical intraepithelial neoplasia (cin) after loop electrosurgical excisional procedure (leep)

目的：探讨重组干扰素α-2b栓在高危型人乳头瘤病毒（HR-HPV）感染宫颈上皮内瘤变（CIN）患者行宫颈环形电切（LEEP）术后的应用。方法：选取就诊的HR-HPV感染的CIN患者110例,随机分为实验组（n=55例）和对照组（n=55例）。两组均于月经干净后3~7d行LEEP术,实验组患者于LEEP术后3d予以重组干扰素α-2b栓1枚阴道内放置,隔日1次,连用3个月,月经期停用。对照组患者除不使用重组干扰素α-2b栓治疗外余治疗同实验组。观察两组患者术后阴道出血量、出血时间及并发症的发生率,术后6个月行阴道镜、HPV检查评估CIN治疗效果及HPV清除率。结果：实验组术后阴道出血量少于对照组（χ2=5.39,P〈0.05）,阴道出血时间短于对照组（χ2=6.07,P〈0.05）。实验组和对照组术后分别出现并发症2例和8例,实验组术后并发症的发生率明显低于对照组（χ2=3.96,P〈0.05）。术后6个月,实验组患者CIN病变治愈率高于对照组（χ2=4.27,P〈0.05）,CIN病变持续或残存率低于对照组（χ2=4.27,P〈0.05）,实验组患者HPV清除率明显高于对照组（χ2=4.95,P〈0.05）。结论：重组干扰素α-2b栓在HRHPV感染的CIN患者行宫颈环形电切术后的应用可减少阴道出血量,缩短阴道出血时间,减少并发症发生率;并可提高CIN病变治愈率,能提高HPV清除率,更有效清除HPV感染。

Objectives： To discuss application of recombinant interferon α- 2b bolt on patients with high-risk human papilloma virus（ HR- HPV） infected with cervical intraepithelial neoplasia（ CIN） after loop electrosurgical excisional procedure（ LEEP）. Methods： 110 patients with HR- HPV infected with CIN were selected and divided into experimental group（ n = 55） and control group（ n = 55） randomly. The patients in both groups were given LEEP 3 ~ 7 days upon the end of menses,and patients in experimental group were given one recombinant interferon α- 2b bolt,which was placed in vagina,3 days after LEEP,every 2 days for 3 months except for menses,while the patients in control group were given the same medical treatment as that in experimental group except for recombinant interferon α- 2b bolt. The postoperative amount of vaginal bleeding,bleeding time,occurrence rate of complication and CIN curative effect and HPV clearance rate by colposcope and HPV test evaluation 6 months after operation of patients in two groups were observed. Results： The postoperative amount of vagina bleeding of patients in experimental group was less than that in control group（ χ2= 5. 39,P〈0. 05） and the bleeding time of patients in experimental group was shorter than that in control group（ χ2= 6. 07,P〈0. 05）. 2 and 8 cases of occurrences of complication appeared on patients in experimental group and control group respectively,and the occurrence rate of complication of patients in experimental group was much lower than that in control group（ χ2= 3. 96,P〈0. 05）.The cure rate of CIN pathological changes of patients in experimental group was higher than that in control group（ χ2= 4. 27,P〈0. 05）; the lasting or survival rates of CIN pathological changes of patients in experimental group were lower than those in control group（ χ2= 4. 27,P〈0. 05） and the HPV clearance rate of patients in experimental group was higher than that in control group（ χ2= 4. 95,P〈0. 05）. Conclusion： The application of recombinantinterferon α- 2b bolt on patients with HR- HPV infected with CIN after LEEP can reduce the amount of vaginal bleeding,shorten bleeding time,reduce occurrence rate of complication,raise CIN cure rate of CIN pathological changes and HPV clearance rate and effectively clear HPV infection.