摘要
三氯蔗糖-6-乙酸酯作为工业上合成生产三氯蔗糖的直接原料,三氯蔗糖-6-乙酸酯收率对三氯蔗糖的成本有很大的影响。在合成三氯蔗糖-6-乙酸酯的过程中,氯化工艺尤为重要,氯化工艺的优劣直接关系到三氯蔗糖-6乙酯的收率和物料中焦油的含量。在氯化的过程中最重要的一步就是Vilsmeier盐生成的反应,通过对比对Vilsmeier盐反应的物料的投料顺序、滴加速率、反应体系温度的控制,确定Vilsmeier盐的最佳反应条件,从而使三氯蔗糖-6-乙酸酯的收率达到最佳,反应过程中对所有的物料进行高效液相色谱法分析,所测得结果与实际结晶相比较相接近。
Sucralose-6–acetate is a raw materials of sucralose production in the industrial synthesis. Sucralose-6-acetate yield greatly influenced the sucralose cost. In the process of synthesis of sucralose-6-acetate,cyanide process is particularly important,chlorination process directly related to the sucralose-6-acetate yield and tar content in the process. The most important step in the processing of chloride is Vilsmeier salt formation reaction. By studying Vilsmeier salt reaction material feeding sequence,dripping speed rate and reaction temperature control system,the optimum reaction conditions of highest yield of sucralose-6-acetate were achieved. The HPLC analysis shows that the actual reaction is very close to the predicted one.
出处
《中国食品添加剂》
CAS
北大核心
2016年第2期96-99,共4页
China Food Additives
